Abstract
The objective of this work, using pharmaceutical and maltodextrin matrices as experimental models, was to study the disintegration and diffusion of solid matrices into water, and the involved interphases generated during these phenomena by means of image and fractal analysis and by the application of nonlinear dynamics. Special diffusion cells were used to observe the disintegration and diffusion of aspirin and of maltodextrin compressed matrices in degasifi ed distilled water without agitation. Digital images were captured at different time intervals during the disintegration phenomena. Images from different perspectives were processed using the appropriate software measuring the fractal dimension ( d f ) values of the perimeter of the matrices. The fractal dimension of the lateral face of the matrices, the number of layers, and the velocity and behavior of turbulences and interphases were observed, and the data were statistically analyzed.
| Original language | English |
|---|---|
| Title of host publication | Water Properties in Food, Health, Pharmaceutical and Biological Systems |
| Subtitle of host publication | ISOPOW 10 |
| Publisher | Wiley-Blackwell |
| Pages | 515-521 |
| Number of pages | 7 |
| ISBN (Print) | 9780813812731 |
| DOIs | |
| State | Published - 14 May 2010 |
Keywords
- Computerized video capture system-digital images captured
- Differences in df kinetics - primary attribution to chemical composition
- Disintegration and diffusion of aspirin - special diffusion cells used
- Fractal geometry - evaluating complexity of biological systems
- Image processing and nonlinear dynamics - disintegration and diffusion evaluation
- Nonlinear dynamics - description of kinetic behavior