TY - JOUR
T1 - A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes
AU - Campos-Vidal, Yrvinn
AU - Zamilpa, Alejandro
AU - Jiménez-Ferrer, Enrique
AU - Jiménez-Aparicio, Antonio Ruperto
AU - Camacho-Díaz, Brenda Hildeliza
AU - Trejo-Tapia, Gabriela
AU - Tapia-Maruri, Daniel
AU - Monterrosas-Brisson, Nayeli
AU - Herrera-Ruiz, Maribel
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.
AB - Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.
KW - Malvaviscus arboreus
KW - catalase
KW - cytokines
KW - histologic analysis
KW - kaempferol-3-O-sambubioside and kaempferol-3-O-sophoroside
UR - http://www.scopus.com/inward/record.url?scp=85141880551&partnerID=8YFLogxK
U2 - 10.3390/plants11212951
DO - 10.3390/plants11212951
M3 - Artículo
C2 - 36365404
AN - SCOPUS:85141880551
SN - 2223-7747
VL - 11
JO - Plants
JF - Plants
IS - 21
M1 - 2951
ER -