A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes

Yrvinn Campos-Vidal; Alejandro Zamilpa; Enrique Jiménez-Ferrer; Antonio Ruperto Jiménez-Aparicio; Brenda Hildeliza Camacho-Díaz; Gabriela Trejo-Tapia; Daniel Tapia-Maruri; Nayeli Monterrosas-Brisson; Maribel Herrera-Ruiz

doi:10.3390/plants11212951

A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes

Yrvinn Campos-Vidal, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Antonio Ruperto Jiménez-Aparicio, Brenda Hildeliza Camacho-Díaz, Gabriela Trejo-Tapia, Daniel Tapia-Maruri, Nayeli Monterrosas-Brisson, Maribel Herrera-Ruiz

Centro de Desarrollo de Productos Bióticos (CEPROBI)

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1 Scopus citations

Abstract

Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.

Original language	English
Article number	2951
Journal	Plants
Volume	11
Issue number	21
DOIs	https://doi.org/10.3390/plants11212951
State	Published - Nov 2022

Keywords

Malvaviscus arboreus
catalase
cytokines
histologic analysis
kaempferol-3-O-sambubioside and kaempferol-3-O-sophoroside

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10.3390/plants11212951

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Campos-Vidal, Y., Zamilpa, A., Jiménez-Ferrer, E., Jiménez-Aparicio, A. R., Camacho-Díaz, B. H., Trejo-Tapia, G., Tapia-Maruri, D., Monterrosas-Brisson, N., & Herrera-Ruiz, M. (2022). A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes. Plants, 11(21), Article 2951. https://doi.org/10.3390/plants11212951

@article{1ffbb22f93ad479fb36807e05219ff9f,

title = "A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes",

abstract = "Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.",

keywords = "Malvaviscus arboreus, catalase, cytokines, histologic analysis, kaempferol-3-O-sambubioside and kaempferol-3-O-sophoroside",

author = "Yrvinn Campos-Vidal and Alejandro Zamilpa and Enrique Jim{\'e}nez-Ferrer and Jim{\'e}nez-Aparicio, {Antonio Ruperto} and Camacho-D{\'i}az, {Brenda Hildeliza} and Gabriela Trejo-Tapia and Daniel Tapia-Maruri and Nayeli Monterrosas-Brisson and Maribel Herrera-Ruiz",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

doi = "10.3390/plants11212951",

language = "Ingl{\'e}s",

volume = "11",

journal = "Plants",

issn = "2223-7747",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "21",

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Campos-Vidal, Y, Zamilpa, A, Jiménez-Ferrer, E, Jiménez-Aparicio, AR , Camacho-Díaz, BH , Trejo-Tapia, G , Tapia-Maruri, D, Monterrosas-Brisson, N & Herrera-Ruiz, M 2022, 'A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes', Plants, vol. 11, no. 21, 2951. https://doi.org/10.3390/plants11212951

A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes. / Campos-Vidal, Yrvinn; Zamilpa, Alejandro; Jiménez-Ferrer, Enrique et al.
In: Plants, Vol. 11, No. 21, 2951, 11.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes

AU - Campos-Vidal, Yrvinn

AU - Zamilpa, Alejandro

AU - Jiménez-Ferrer, Enrique

AU - Jiménez-Aparicio, Antonio Ruperto

AU - Camacho-Díaz, Brenda Hildeliza

AU - Trejo-Tapia, Gabriela

AU - Tapia-Maruri, Daniel

AU - Monterrosas-Brisson, Nayeli

AU - Herrera-Ruiz, Maribel

PY - 2022/11

Y1 - 2022/11

N2 - Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.

AB - Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.

KW - Malvaviscus arboreus

KW - catalase

KW - cytokines

KW - histologic analysis

KW - kaempferol-3-O-sambubioside and kaempferol-3-O-sophoroside

UR - http://www.scopus.com/inward/record.url?scp=85141880551&partnerID=8YFLogxK

U2 - 10.3390/plants11212951

DO - 10.3390/plants11212951

M3 - Artículo

C2 - 36365404

AN - SCOPUS:85141880551

SN - 2223-7747

VL - 11

JO - Plants

JF - Plants

IS - 21

M1 - 2951

ER -

A Mixture of Kaempferol-3-O-sambubioside and Kaempferol-3-O-sophoroside from Malvaviscus arboreus Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes

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Keywords

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