The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

Elizdath Martínez; Alberto García; Angel Saenz; Leticia Garduño; María Salazar; Germán Chamorro

doi:10.1076/phbi.41.6.449.17824

The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

Elizdath Martínez, Alberto García, Angel Saenz, Leticia Garduño, María Salazar, Germán Chamorro

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA_1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA _1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

Idioma original	Inglés
Páginas (desde-hasta)	449-453
Número de páginas	5
Publicación	Pharmaceutical Biology
Volumen	41
N.º	6
DOI	https://doi.org/10.1076/phbi.41.6.449.17824
Estado	Publicada - sep. 2003

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title = "The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice",

abstract = "The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.",

keywords = "Diabetes, Embryotoxicity, Glycation, Glycine, Teratogenesis",

author = "Elizdath Mart{\'i}nez and Alberto Garc{\'i}a and Angel Saenz and Leticia Gardu{\~n}o and Mar{\'i}a Salazar and Germ{\'a}n Chamorro",

note = "Funding Information: This study was supported by the Coordinaci{\'o}n General de Posgrado e Investigaci{\'o}n del Instituto Polit{\'e}cnico Nacional (Grant 980406). G.C. We wish to thank the Instituto Polit{\'e}c-nico Nacional for scholarships awarded. A special acknowledgment is due to Dr. E. Ram{\'i}rez for his advice on statistical issues and Ms. N. Paniagua, MSc for her lessons on the skeletal procedure.",

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doi = "10.1076/phbi.41.6.449.17824",

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AU - Martínez, Elizdath

AU - García, Alberto

AU - Saenz, Angel

AU - Garduño, Leticia

AU - Salazar, María

AU - Chamorro, Germán

N1 - Funding Information: This study was supported by the Coordinación General de Posgrado e Investigación del Instituto Politécnico Nacional (Grant 980406). G.C. We wish to thank the Instituto Politéc-nico Nacional for scholarships awarded. A special acknowledgment is due to Dr. E. Ramírez for his advice on statistical issues and Ms. N. Paniagua, MSc for her lessons on the skeletal procedure.

PY - 2003/9

Y1 - 2003/9

N2 - The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

AB - The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

KW - Diabetes

KW - Embryotoxicity

KW - Glycation

KW - Glycine

KW - Teratogenesis

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DO - 10.1076/phbi.41.6.449.17824

M3 - Artículo

SN - 1388-0209

VL - 41

SP - 449

EP - 453

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 6

ER -

The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

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