The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

Elizdath Martínez; Alberto García; Angel Saenz; Leticia Garduño; María Salazar; Germán Chamorro

doi:10.1076/phbi.41.6.449.17824

The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

Elizdath Martínez, Alberto García, Angel Saenz, Leticia Garduño, María Salazar, Germán Chamorro

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA_1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA _1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

Original language	English
Pages (from-to)	449-453
Number of pages	5
Journal	Pharmaceutical Biology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1076/phbi.41.6.449.17824
State	Published - Sep 2003

Keywords

Diabetes
Embryotoxicity
Glycation
Glycine
Teratogenesis

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10.1076/phbi.41.6.449.17824

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title = "The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice",

abstract = "The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.",

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author = "Elizdath Mart{\'i}nez and Alberto Garc{\'i}a and Angel Saenz and Leticia Gardu{\~n}o and Mar{\'i}a Salazar and Germ{\'a}n Chamorro",

note = "Funding Information: This study was supported by the Coordinaci{\'o}n General de Posgrado e Investigaci{\'o}n del Instituto Polit{\'e}cnico Nacional (Grant 980406). G.C. We wish to thank the Instituto Polit{\'e}c-nico Nacional for scholarships awarded. A special acknowledgment is due to Dr. E. Ram{\'i}rez for his advice on statistical issues and Ms. N. Paniagua, MSc for her lessons on the skeletal procedure.",

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AU - García, Alberto

AU - Saenz, Angel

AU - Garduño, Leticia

AU - Salazar, María

AU - Chamorro, Germán

N1 - Funding Information: This study was supported by the Coordinación General de Posgrado e Investigación del Instituto Politécnico Nacional (Grant 980406). G.C. We wish to thank the Instituto Politéc-nico Nacional for scholarships awarded. A special acknowledgment is due to Dr. E. Ramírez for his advice on statistical issues and Ms. N. Paniagua, MSc for her lessons on the skeletal procedure.

PY - 2003/9

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N2 - The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

AB - The effect of glycine in preventing diabetes teratogenicity was studied in mice. Pregnant female animals were given an IP injection of 200mg/kg of streptozotocin (STZ) on gestation day (GD) 7. Glycine was administered ad libitum from GD9 through GD19 (day of sacrifice) as a 1 and 2% drinking water solution. Nine whole-litter resorptions, a decreased number of live fetuses and fetal parameters, and an increase in HbA1C levels in diabetic dams were found. Malformations were limited. Glycine had a protective effect from hemoglobin glycation and embryotoxicity due to STZ-induced diabetes. Also, resorptions and malformed fetuses were positively correlated to HbA 1C levels with a negative correlation to the number of live fetuses. The data suggest that glycine reduces the embryolethality of STZ-induced diabetes due to its anti-glycation effect.

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KW - Embryotoxicity

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The Effects of Glycine Therapy on the Fetal Outcome of Diabetic Mice

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