TY - JOUR
T1 - The attempt to demolish the science and practice of preventive cardiovascular medicine. Part I Addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANIAM and the joint group of associated medical societies
AU - Meaney, Eduardo
AU - Barros, Carlos Leonardo Fernandez
AU - Munoz, Jose Manuel Enciso
AU - Reyes, Guillermo Ceballos
AU - Najera, Nayelli
AU - Hernandez, Francisco Javier Leon
AU - Orozco, Jorge Hilario Jimenez
AU - Corrales, Marco Antonio Ramos
AU - Alvarez, Enrique Gomez
AU - Barragan, Adriana Puente
AU - Chauvet, Alejandro Alcocer
AU - Lopez, Arturo Guerra
AU - Aragon, Alejo Diaz
N1 - Publisher Copyright:
© 2018 Asociacion Nacional de Cardiologos de Mexico. All Rights Reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - This manuscript is an addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANCAM and the joint group of associated medical societies, already published. It is the fi rst part of a wider refl ection aimed on refute several of the theses and arguments of a group of clinicians and researchers who question the validity of the "cholesterol hypothesis", the usefulness and safety of statins and the most modern inhibitors of proprotein convertase of subtilisin/kexin type 9 (iPCSK9,) and the role of saturated fatty acids consumed in the usual diet in the atherosclerotic risk. This iconoclastic point of view is dangerous insofar as it undermines the scaff olding that supports the primary and secondary prevention of atherosclerosis. In this section of the manuscript, only the cholesterol hypothesis is discussed. The data of comparative zoology are reviewed, and several experimental animal models are analyzed, both supporting the link between cholesterol and the appearance and evolution of atherosclerotic lesions. The methodology and the results of the Study of the 7 Countries are defended and are exposed the numerous epidemiological, pathological, clinical and interventional evidences, which in our opinion give a solid sustenance to the cholesterol hypothesis. Based on this knowledge it is criticized the LDL cholesterol values currently considered adequate. Furthermore, the so-called residual risk is considered, as well as the confl icting evidence about the usefulness of statins in elderly patients.
AB - This manuscript is an addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANCAM and the joint group of associated medical societies, already published. It is the fi rst part of a wider refl ection aimed on refute several of the theses and arguments of a group of clinicians and researchers who question the validity of the "cholesterol hypothesis", the usefulness and safety of statins and the most modern inhibitors of proprotein convertase of subtilisin/kexin type 9 (iPCSK9,) and the role of saturated fatty acids consumed in the usual diet in the atherosclerotic risk. This iconoclastic point of view is dangerous insofar as it undermines the scaff olding that supports the primary and secondary prevention of atherosclerosis. In this section of the manuscript, only the cholesterol hypothesis is discussed. The data of comparative zoology are reviewed, and several experimental animal models are analyzed, both supporting the link between cholesterol and the appearance and evolution of atherosclerotic lesions. The methodology and the results of the Study of the 7 Countries are defended and are exposed the numerous epidemiological, pathological, clinical and interventional evidences, which in our opinion give a solid sustenance to the cholesterol hypothesis. Based on this knowledge it is criticized the LDL cholesterol values currently considered adequate. Furthermore, the so-called residual risk is considered, as well as the confl icting evidence about the usefulness of statins in elderly patients.
KW - Atherogenesis in animals
KW - Cholesterol hypothesis
KW - Hypercholesterolemia
KW - Inhibitors of PCSK9
KW - Statins
KW - Study of7 Countries
UR - http://www.scopus.com/inward/record.url?scp=85061125596&partnerID=8YFLogxK
M3 - Artículo de revisión
SN - 0188-2198
VL - 29
SP - 173
EP - 187
JO - Revista Mexicana de Cardiologia
JF - Revista Mexicana de Cardiologia
IS - 4
ER -