The attempt to demolish the science and practice of preventive cardiovascular medicine. Part I Addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANIAM and the joint group of associated medical societies

Eduardo Meaney, Carlos Leonardo Fernandez Barros, Jose Manuel Enciso Munoz, Guillermo Ceballos Reyes, Nayelli Najera, Francisco Javier Leon Hernandez, Jorge Hilario Jimenez Orozco, Marco Antonio Ramos Corrales, Enrique Gomez Alvarez, Adriana Puente Barragan, Alejandro Alcocer Chauvet, Arturo Guerra Lopez, Alejo Diaz Aragon

Research output: Contribution to journalReview articlepeer-review

Abstract

This manuscript is an addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANCAM and the joint group of associated medical societies, already published. It is the fi rst part of a wider refl ection aimed on refute several of the theses and arguments of a group of clinicians and researchers who question the validity of the "cholesterol hypothesis", the usefulness and safety of statins and the most modern inhibitors of proprotein convertase of subtilisin/kexin type 9 (iPCSK9,) and the role of saturated fatty acids consumed in the usual diet in the atherosclerotic risk. This iconoclastic point of view is dangerous insofar as it undermines the scaff olding that supports the primary and secondary prevention of atherosclerosis. In this section of the manuscript, only the cholesterol hypothesis is discussed. The data of comparative zoology are reviewed, and several experimental animal models are analyzed, both supporting the link between cholesterol and the appearance and evolution of atherosclerotic lesions. The methodology and the results of the Study of the 7 Countries are defended and are exposed the numerous epidemiological, pathological, clinical and interventional evidences, which in our opinion give a solid sustenance to the cholesterol hypothesis. Based on this knowledge it is criticized the LDL cholesterol values currently considered adequate. Furthermore, the so-called residual risk is considered, as well as the confl icting evidence about the usefulness of statins in elderly patients.

Original languageEnglish
Pages (from-to)173-187
Number of pages15
JournalRevista Mexicana de Cardiologia
Volume29
Issue number4
StatePublished - 1 Oct 2018
Externally publishedYes

Keywords

  • Atherogenesis in animals
  • Cholesterol hypothesis
  • Hypercholesterolemia
  • Inhibitors of PCSK9
  • Statins
  • Study of7 Countries

Fingerprint

Dive into the research topics of 'The attempt to demolish the science and practice of preventive cardiovascular medicine. Part I Addendum to the positioning around the diagnosis and treatment of dyslipidemias of ANIAM and the joint group of associated medical societies'. Together they form a unique fingerprint.

Cite this