Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico

Background: The true prevalence of Chagas disease in Mexico is unknown. However, it has been estimated that 1.1–4 million people are infected with Trypanosoma cruzi, which represents a potential risk for transmission of the disease via contaminated blood. Aim of the Study: To determine the Chagas disease seroprevalence in donors from eight blood banks in the north of Mexico City, and the northeast of the State of Mexico. Study Design and Methods: Serum samples from blood donors (n = 515,038) were tested to detect the presence of anti-Trypanosoma cruzi antibodies in eight blood banks. The serologic screening test was performed in each of the blood banks. To confirm the seropositive blood donors, only two out of the eight blood banks used a test with a different principle with the aim of identifying anti-Trypanosoma cruzi antibodies. All tests were validated by the Mexican Institute for Epidemiological Diagnosis and Reference. Results: One thousand two hundred and ten blood donors were seropositive for Trypanosoma cruzi, which represents a 0.23% seroprevalence (95% CI 0.22–0.25%). Of the seropositive blood donors, 97.03 % resided in the northeast area of the State of Mexico, Mexico City, and southern part of the State of Hidalgo. Conclusions: Active transmission of Chagas disease may be occurring in non-endemic regions in the northeast of the State of Mexico.