Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico

Saúl González-Guzmán; Patricia González-Cano; Edward T. Bagu; Salvador Vázquez-Vega; Martha Martínez-Salazar; Margarita Juárez-Montiel; Adriana Gutiérrez-Hoya; José A. Crescencio-Trujillo; Sokani Sánchez-Montes; Edith Fernández-Figueroa; Erik A. Contreras-López; Ángel Guerra-Márquez; Carla I. Arroyo-Anduiza; Laura E. Ángeles-Márquez; Eduardo Rodríguez-Trejo; Carolina Bekker-Méndez; Francisco X. Guerra-Castillo; Citlalli Regalado-Santiago; Emiliano Tesoro-Cruz; Norma Oviedo; Ana M. Victoria-Jardón; Jesús Bautista-Olvera; Pedro García-Ramírez; José E. Vázquez-Meraz; María C. Contreras-Lozano; Verónica S. Castillo-Flores; Rogelio Guevara-Reyes; Alma R. Girón-Sánchez; H. D. Arenas-Luis; María José Pecero-Hidalgo; Emiliano Ríos-Antonio; Natividad Ramírez-Pereda; Adalberto Martínez-Mora; Vladimir Paredes-Cervantes

doi:10.1016/j.arcmed.2022.08.007

Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico

Saúl González-Guzmán, Patricia González-Cano, Edward T. Bagu, Salvador Vázquez-Vega, Martha Martínez-Salazar, Margarita Juárez-Montiel, Adriana Gutiérrez-Hoya, José A. Crescencio-Trujillo, Sokani Sánchez-Montes, Edith Fernández-Figueroa, Erik A. Contreras-López, Ángel Guerra-Márquez, Carla I. Arroyo-Anduiza, Laura E. Ángeles-Márquez, Eduardo Rodríguez-Trejo, Carolina Bekker-Méndez, Francisco X. Guerra-Castillo, Citlalli Regalado-Santiago, Emiliano Tesoro-Cruz, Norma OviedoAna M. Victoria-Jardón, Jesús Bautista-Olvera, Pedro García-Ramírez, José E. Vázquez-Meraz, María C. Contreras-Lozano, Verónica S. Castillo-Flores, Rogelio Guevara-Reyes, Alma R. Girón-Sánchez, H. D. Arenas-Luis, María José Pecero-Hidalgo, Emiliano Ríos-Antonio, Natividad Ramírez-Pereda, Adalberto Martínez-Mora, Vladimir Paredes-Cervantes

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The true prevalence of Chagas disease in Mexico is unknown. However, it has been estimated that 1.1–4 million people are infected with Trypanosoma cruzi, which represents a potential risk for transmission of the disease via contaminated blood. Aim of the Study: To determine the Chagas disease seroprevalence in donors from eight blood banks in the north of Mexico City, and the northeast of the State of Mexico. Study Design and Methods: Serum samples from blood donors (n = 515,038) were tested to detect the presence of anti-Trypanosoma cruzi antibodies in eight blood banks. The serologic screening test was performed in each of the blood banks. To confirm the seropositive blood donors, only two out of the eight blood banks used a test with a different principle with the aim of identifying anti-Trypanosoma cruzi antibodies. All tests were validated by the Mexican Institute for Epidemiological Diagnosis and Reference. Results: One thousand two hundred and ten blood donors were seropositive for Trypanosoma cruzi, which represents a 0.23% seroprevalence (95% CI 0.22–0.25%). Of the seropositive blood donors, 97.03 % resided in the northeast area of the State of Mexico, Mexico City, and southern part of the State of Hidalgo. Conclusions: Active transmission of Chagas disease may be occurring in non-endemic regions in the northeast of the State of Mexico.

Original language	English
Pages (from-to)	625-633
Number of pages	9
Journal	Archives of Medical Research
Volume	53
Issue number	6
DOIs	https://doi.org/10.1016/j.arcmed.2022.08.007
State	Published - Sep 2022

Keywords

Blood Banks
Blood Donors
Mexico
Seroprevalence
Trypanosoma cruzi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.arcmed.2022.08.007

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González-Guzmán, S., González-Cano, P., Bagu, E. T., Vázquez-Vega, S., Martínez-Salazar, M., Juárez-Montiel, M., Gutiérrez-Hoya, A., Crescencio-Trujillo, J. A., Sánchez-Montes, S., Fernández-Figueroa, E., Contreras-López, E. A., Guerra-Márquez, Á., Arroyo-Anduiza, C. I., Ángeles-Márquez, L. E., Rodríguez-Trejo, E., Bekker-Méndez, C., Guerra-Castillo, F. X., Regalado-Santiago, C., Tesoro-Cruz, E., ... Paredes-Cervantes, V. (2022). Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico. Archives of Medical Research, 53(6), 625-633. https://doi.org/10.1016/j.arcmed.2022.08.007

@article{baa1f3f846a9471f90de8668f8462221,

title = "Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico",

abstract = "Background: The true prevalence of Chagas disease in Mexico is unknown. However, it has been estimated that 1.1–4 million people are infected with Trypanosoma cruzi, which represents a potential risk for transmission of the disease via contaminated blood. Aim of the Study: To determine the Chagas disease seroprevalence in donors from eight blood banks in the north of Mexico City, and the northeast of the State of Mexico. Study Design and Methods: Serum samples from blood donors (n = 515,038) were tested to detect the presence of anti-Trypanosoma cruzi antibodies in eight blood banks. The serologic screening test was performed in each of the blood banks. To confirm the seropositive blood donors, only two out of the eight blood banks used a test with a different principle with the aim of identifying anti-Trypanosoma cruzi antibodies. All tests were validated by the Mexican Institute for Epidemiological Diagnosis and Reference. Results: One thousand two hundred and ten blood donors were seropositive for Trypanosoma cruzi, which represents a 0.23% seroprevalence (95% CI 0.22–0.25%). Of the seropositive blood donors, 97.03 % resided in the northeast area of the State of Mexico, Mexico City, and southern part of the State of Hidalgo. Conclusions: Active transmission of Chagas disease may be occurring in non-endemic regions in the northeast of the State of Mexico.",

keywords = "Blood Banks, Blood Donors, Mexico, Seroprevalence, Trypanosoma cruzi",

author = "Sa{\'u}l Gonz{\'a}lez-Guzm{\'a}n and Patricia Gonz{\'a}lez-Cano and Bagu, {Edward T.} and Salvador V{\'a}zquez-Vega and Martha Mart{\'i}nez-Salazar and Margarita Ju{\'a}rez-Montiel and Adriana Guti{\'e}rrez-Hoya and Crescencio-Trujillo, {Jos{\'e} A.} and Sokani S{\'a}nchez-Montes and Edith Fern{\'a}ndez-Figueroa and Contreras-L{\'o}pez, {Erik A.} and {\'A}ngel Guerra-M{\'a}rquez and Arroyo-Anduiza, {Carla I.} and {\'A}ngeles-M{\'a}rquez, {Laura E.} and Eduardo Rodr{\'i}guez-Trejo and Carolina Bekker-M{\'e}ndez and Guerra-Castillo, {Francisco X.} and Citlalli Regalado-Santiago and Emiliano Tesoro-Cruz and Norma Oviedo and Victoria-Jard{\'o}n, {Ana M.} and Jes{\'u}s Bautista-Olvera and Pedro Garc{\'i}a-Ram{\'i}rez and V{\'a}zquez-Meraz, {Jos{\'e} E.} and Contreras-Lozano, {Mar{\'i}a C.} and Castillo-Flores, {Ver{\'o}nica S.} and Rogelio Guevara-Reyes and Gir{\'o}n-S{\'a}nchez, {Alma R.} and Arenas-Luis, {H. D.} and Pecero-Hidalgo, {Mar{\'i}a Jos{\'e}} and Emiliano R{\'i}os-Antonio and Natividad Ram{\'i}rez-Pereda and Adalberto Mart{\'i}nez-Mora and Vladimir Paredes-Cervantes",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = sep,

doi = "10.1016/j.arcmed.2022.08.007",

language = "Ingl{\'e}s",

volume = "53",

pages = "625--633",

journal = "Archives of Medical Research",

issn = "0188-4409",

number = "6",

}

González-Guzmán, S, González-Cano, P, Bagu, ET, Vázquez-Vega, S, Martínez-Salazar, M, Juárez-Montiel, M, Gutiérrez-Hoya, A, Crescencio-Trujillo, JA, Sánchez-Montes, S, Fernández-Figueroa, E, Contreras-López, EA, Guerra-Márquez, Á, Arroyo-Anduiza, CI, Ángeles-Márquez, LE, Rodríguez-Trejo, E, Bekker-Méndez, C, Guerra-Castillo, FX, Regalado-Santiago, C, Tesoro-Cruz, E, Oviedo, N, Victoria-Jardón, AM, Bautista-Olvera, J, García-Ramírez, P, Vázquez-Meraz, JE, Contreras-Lozano, MC, Castillo-Flores, VS, Guevara-Reyes, R, Girón-Sánchez, AR, Arenas-Luis, HD, Pecero-Hidalgo, MJ, Ríos-Antonio, E, Ramírez-Pereda, N, Martínez-Mora, A & Paredes-Cervantes, V 2022, 'Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico', Archives of Medical Research, vol. 53, no. 6, pp. 625-633. https://doi.org/10.1016/j.arcmed.2022.08.007

TY - JOUR

T1 - Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico

AU - González-Guzmán, Saúl

AU - González-Cano, Patricia

AU - Bagu, Edward T.

AU - Vázquez-Vega, Salvador

AU - Martínez-Salazar, Martha

AU - Juárez-Montiel, Margarita

AU - Gutiérrez-Hoya, Adriana

AU - Crescencio-Trujillo, José A.

AU - Sánchez-Montes, Sokani

AU - Fernández-Figueroa, Edith

AU - Contreras-López, Erik A.

AU - Guerra-Márquez, Ángel

AU - Arroyo-Anduiza, Carla I.

AU - Ángeles-Márquez, Laura E.

AU - Rodríguez-Trejo, Eduardo

AU - Bekker-Méndez, Carolina

AU - Guerra-Castillo, Francisco X.

AU - Regalado-Santiago, Citlalli

AU - Tesoro-Cruz, Emiliano

AU - Oviedo, Norma

AU - Victoria-Jardón, Ana M.

AU - Bautista-Olvera, Jesús

AU - García-Ramírez, Pedro

AU - Vázquez-Meraz, José E.

AU - Contreras-Lozano, María C.

AU - Castillo-Flores, Verónica S.

AU - Guevara-Reyes, Rogelio

AU - Girón-Sánchez, Alma R.

AU - Arenas-Luis, H. D.

AU - Pecero-Hidalgo, María José

AU - Ríos-Antonio, Emiliano

AU - Ramírez-Pereda, Natividad

AU - Martínez-Mora, Adalberto

AU - Paredes-Cervantes, Vladimir

PY - 2022/9

Y1 - 2022/9

N2 - Background: The true prevalence of Chagas disease in Mexico is unknown. However, it has been estimated that 1.1–4 million people are infected with Trypanosoma cruzi, which represents a potential risk for transmission of the disease via contaminated blood. Aim of the Study: To determine the Chagas disease seroprevalence in donors from eight blood banks in the north of Mexico City, and the northeast of the State of Mexico. Study Design and Methods: Serum samples from blood donors (n = 515,038) were tested to detect the presence of anti-Trypanosoma cruzi antibodies in eight blood banks. The serologic screening test was performed in each of the blood banks. To confirm the seropositive blood donors, only two out of the eight blood banks used a test with a different principle with the aim of identifying anti-Trypanosoma cruzi antibodies. All tests were validated by the Mexican Institute for Epidemiological Diagnosis and Reference. Results: One thousand two hundred and ten blood donors were seropositive for Trypanosoma cruzi, which represents a 0.23% seroprevalence (95% CI 0.22–0.25%). Of the seropositive blood donors, 97.03 % resided in the northeast area of the State of Mexico, Mexico City, and southern part of the State of Hidalgo. Conclusions: Active transmission of Chagas disease may be occurring in non-endemic regions in the northeast of the State of Mexico.

AB - Background: The true prevalence of Chagas disease in Mexico is unknown. However, it has been estimated that 1.1–4 million people are infected with Trypanosoma cruzi, which represents a potential risk for transmission of the disease via contaminated blood. Aim of the Study: To determine the Chagas disease seroprevalence in donors from eight blood banks in the north of Mexico City, and the northeast of the State of Mexico. Study Design and Methods: Serum samples from blood donors (n = 515,038) were tested to detect the presence of anti-Trypanosoma cruzi antibodies in eight blood banks. The serologic screening test was performed in each of the blood banks. To confirm the seropositive blood donors, only two out of the eight blood banks used a test with a different principle with the aim of identifying anti-Trypanosoma cruzi antibodies. All tests were validated by the Mexican Institute for Epidemiological Diagnosis and Reference. Results: One thousand two hundred and ten blood donors were seropositive for Trypanosoma cruzi, which represents a 0.23% seroprevalence (95% CI 0.22–0.25%). Of the seropositive blood donors, 97.03 % resided in the northeast area of the State of Mexico, Mexico City, and southern part of the State of Hidalgo. Conclusions: Active transmission of Chagas disease may be occurring in non-endemic regions in the northeast of the State of Mexico.

KW - Blood Banks

KW - Blood Donors

KW - Mexico

KW - Seroprevalence

KW - Trypanosoma cruzi

UR - http://www.scopus.com/inward/record.url?scp=85137938468&partnerID=8YFLogxK

U2 - 10.1016/j.arcmed.2022.08.007

DO - 10.1016/j.arcmed.2022.08.007

M3 - Artículo

C2 - 36109203

AN - SCOPUS:85137938468

SN - 0188-4409

VL - 53

SP - 625

EP - 633

JO - Archives of Medical Research

JF - Archives of Medical Research

IS - 6

ER -

Seroprevalence of Trypanosoma cruzi in Eight Blood Banks in Mexico

Abstract

Keywords

UN SDGs

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