Renoprotection byα-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity

Jazmin M. Pérez-Rojas, Cristino Cruz, Patricia García-López, Dolores J. Sánchez-González, Claudia M. Martínez-Martínez, Gisela Ceballos, Magali Espinosa, Jorge Meléndez-Zajgla, Jos Pedraza-Chaverri

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

77 Citas (Scopus)

Resumen

Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress.-Mangostin (-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of-M on the CDDP-induced nephrotoxicity.-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed.-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity.

Idioma originalInglés
Páginas (desde-hasta)1122-1132
Número de páginas11
PublicaciónFree Radical Research
Volumen43
N.º11
DOI
EstadoPublicada - 2009
Publicado de forma externa

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