TY - JOUR
T1 - Renoprotection byα-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity
AU - Pérez-Rojas, Jazmin M.
AU - Cruz, Cristino
AU - García-López, Patricia
AU - Sánchez-González, Dolores J.
AU - Martínez-Martínez, Claudia M.
AU - Ceballos, Gisela
AU - Espinosa, Magali
AU - Meléndez-Zajgla, Jorge
AU - Pedraza-Chaverri, Jos
N1 - Funding Information:
This work was supported by DGAPA IN207007. Jazmin M Pérez-Rojas received a postdoctoral fellowship from UNAM through DGAPA. This work was presented in part at the XXVII National Meeting of Biochemistry, 16·22 November 2008, Merida, Yucatan, Mexico and the XV SLANH Meeting, 15·19 April 2009, Mexico City, Mexico.
PY - 2009
Y1 - 2009
N2 - Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress.-Mangostin (-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of-M on the CDDP-induced nephrotoxicity.-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed.-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity.
AB - Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress.-Mangostin (-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of-M on the CDDP-induced nephrotoxicity.-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed.-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity.
KW - Alpha-mangostin
KW - Anti-inflammatory
KW - Antioxidant
KW - Catalase
KW - Cisplatin
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=70350532742&partnerID=8YFLogxK
U2 - 10.1080/10715760903214447
DO - 10.1080/10715760903214447
M3 - Artículo
SN - 1071-5762
VL - 43
SP - 1122
EP - 1132
JO - Free Radical Research
JF - Free Radical Research
IS - 11
ER -