Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet

Itzel Ivonn López-Tenorio; Aarón Domínguez-López; Ángel Miliar-García; Gerardo Norberto Escalona-Cardoso; Samantha Alejandra Real-Sandoval; Alejandro Gómez-Alcalá; María Eugenia Jaramillo-Flores

doi:10.1016/j.foodres.2020.109706

Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet

Itzel Ivonn López-Tenorio, Aarón Domínguez-López, Ángel Miliar-García, Gerardo Norberto Escalona-Cardoso, Samantha Alejandra Real-Sandoval, Alejandro Gómez-Alcalá, María Eugenia Jaramillo-Flores

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Resumen

Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.

Idioma original	Inglés
Número de artículo	109706
Publicación	Food Research International
Volumen	137
DOI	https://doi.org/10.1016/j.foodres.2020.109706
Estado	Publicada - nov. 2020

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López-Tenorio, I. I., Domínguez-López, A., Miliar-García, Á., Escalona-Cardoso, G. N., Real-Sandoval, S. A., Gómez-Alcalá, A., & Jaramillo-Flores, M. E. (2020). Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet. Food Research International, 137, Artículo 109706. https://doi.org/10.1016/j.foodres.2020.109706

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title = "Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet",

abstract = "Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.",

keywords = "Inflammasome, Liver, Morin, Nlrp3, Obesity, PUFAs, mRNA",

author = "L{\'o}pez-Tenorio, {Itzel Ivonn} and Aar{\'o}n Dom{\'i}nguez-L{\'o}pez and {\'A}ngel Miliar-Garc{\'i}a and Escalona-Cardoso, {Gerardo Norberto} and Real-Sandoval, {Samantha Alejandra} and Alejandro G{\'o}mez-Alcal{\'a} and Jaramillo-Flores, {Mar{\'i}a Eugenia}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = nov,

doi = "10.1016/j.foodres.2020.109706",

language = "Ingl{\'e}s",

volume = "137",

journal = "Food Research International",

issn = "0963-9969",

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AU - López-Tenorio, Itzel Ivonn

AU - Domínguez-López, Aarón

AU - Miliar-García, Ángel

AU - Escalona-Cardoso, Gerardo Norberto

AU - Real-Sandoval, Samantha Alejandra

AU - Gómez-Alcalá, Alejandro

AU - Jaramillo-Flores, María Eugenia

PY - 2020/11

Y1 - 2020/11

N2 - Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.

AB - Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.

KW - Inflammasome

KW - Liver

KW - Morin

KW - Nlrp3

KW - Obesity

KW - PUFAs

KW - mRNA

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DO - 10.1016/j.foodres.2020.109706

M3 - Artículo

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SN - 0963-9969

VL - 137

JO - Food Research International

JF - Food Research International

M1 - 109706

ER -

Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet

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