TY - JOUR
T1 - Modulation of the mRNA of the Nlrp3 inflammasome by Morin and PUFAs in an obesity model induced by a high-fat diet
AU - López-Tenorio, Itzel Ivonn
AU - Domínguez-López, Aarón
AU - Miliar-García, Ángel
AU - Escalona-Cardoso, Gerardo Norberto
AU - Real-Sandoval, Samantha Alejandra
AU - Gómez-Alcalá, Alejandro
AU - Jaramillo-Flores, María Eugenia
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.
AB - Morin and PUFAs are bioactive compounds provided by the diet, with multiple biological activities, among which are the modulation of inflammation in various chronic diseases. The effect of supplementation with Morin, PUFAs, and the mixture of both on the levels of mRNA expression of the Nlrp3 inflammasome as well as genes associated with inflammation and lipid metabolism, in an obesity model through a high-fat diet, during 8 weeks of administration were evaluated. The three treatments negatively regulated the expression of Nlrp3 mRNA. Morin showed a better effect by modulating downwards the expression of the mRNA of Il-18, Casp-1, Pparγ, and Serbp-1c, in addition to positively modulating the expression of the mRNA of Ppar-α, as well as Adiponectin. The combined treatment of Morin plus the PUFAs maintained similar levels under normal conditions for the mRNA expression of Tlr4 and Ucp2.
KW - Inflammasome
KW - Liver
KW - Morin
KW - Nlrp3
KW - Obesity
KW - PUFAs
KW - mRNA
UR - http://www.scopus.com/inward/record.url?scp=85091625048&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2020.109706
DO - 10.1016/j.foodres.2020.109706
M3 - Artículo
C2 - 33233280
AN - SCOPUS:85091625048
SN - 0963-9969
VL - 137
JO - Food Research International
JF - Food Research International
M1 - 109706
ER -
