TY - JOUR
T1 - Methylphenidate lacks genotoxic effects in mouse peripheral blood erythrocytes
AU - Zamora-Perez, Ana L.
AU - Lazalde-Ramos, Blanca P.
AU - Sosa-Macías, Martha G.
AU - Gómez-Meda, Belinda C.
AU - Torres-Bugarín, Olivia
AU - Zúñiga-González, Guillermo M.
PY - 2011/7
Y1 - 2011/7
N2 - Methylphenidate (MPH; Ritalin®; Novartis Pharmaceuticals, Inc., Basel, Switzerland) has been prescribed to treat attention deficit/hyperactivity disorder (ADHD) since its approval by the U.S. Food and Drug Administration over 50 years ago. Due to concerns that MPH might induce cytogenetic alterations in children, treatment with this drug has been a controversial issue. In the present study, we assessed the frequency of micronucleated erythrocytes (MNEs), micronucleated polychromatic erythrocytes (MNPCEs), and polychromatic erythrocytes (PCEs) in peripheral blood samples from mice treated with three different doses of MPH (30, 60, or 125 mg/kg). We found no evidence of increased MNEs or MNPCEs, nor did PCEs decline. These results add to the accumulating evidence that MPH does not induce genotoxic or cytotoxic damage.
AB - Methylphenidate (MPH; Ritalin®; Novartis Pharmaceuticals, Inc., Basel, Switzerland) has been prescribed to treat attention deficit/hyperactivity disorder (ADHD) since its approval by the U.S. Food and Drug Administration over 50 years ago. Due to concerns that MPH might induce cytogenetic alterations in children, treatment with this drug has been a controversial issue. In the present study, we assessed the frequency of micronucleated erythrocytes (MNEs), micronucleated polychromatic erythrocytes (MNPCEs), and polychromatic erythrocytes (PCEs) in peripheral blood samples from mice treated with three different doses of MPH (30, 60, or 125 mg/kg). We found no evidence of increased MNEs or MNPCEs, nor did PCEs decline. These results add to the accumulating evidence that MPH does not induce genotoxic or cytotoxic damage.
KW - Genotoxicity
KW - Ritalin
KW - micronuclei
KW - mouse
KW - peripheral blood erythrocytes
UR - http://www.scopus.com/inward/record.url?scp=79958185815&partnerID=8YFLogxK
U2 - 10.3109/01480545.2010.536770
DO - 10.3109/01480545.2010.536770
M3 - Artículo
C2 - 21649484
AN - SCOPUS:79958185815
SN - 0148-0545
VL - 34
SP - 294
EP - 299
JO - Drug and Chemical Toxicology
JF - Drug and Chemical Toxicology
IS - 3
ER -
