TY - JOUR
T1 - Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism
AU - González-García, Luis Didier
AU - Martínez-Castillo, Macario
AU - Vargas-Pavía, Tania Allin
AU - Ulloa-Aguilar, José Manuel
AU - Arévalo-Romero, Haruki
AU - Léon-Reyes, Guadalupe
AU - Helguera-Repetto, Addy Cecilia
AU - García-Cordero, Julio
AU - León-Juárez, Moisés
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature.
PY - 2021/4
Y1 - 2021/4
N2 - Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.
AB - Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.
UR - http://www.scopus.com/inward/record.url?scp=85101467503&partnerID=8YFLogxK
U2 - 10.1007/s00705-021-04974-7
DO - 10.1007/s00705-021-04974-7
M3 - Artículo
C2 - 33580381
AN - SCOPUS:85101467503
SN - 0304-8608
VL - 166
SP - 1177
EP - 1182
JO - Archives of Virology
JF - Archives of Virology
IS - 4
ER -