Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

Luis Didier González-García; Macario Martínez-Castillo; Tania Allin Vargas-Pavía; José Manuel Ulloa-Aguilar; Haruki Arévalo-Romero; Guadalupe Léon-Reyes; Addy Cecilia Helguera-Repetto; Julio García-Cordero; Moisés León-Juárez

doi:10.1007/s00705-021-04974-7

Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

Luis Didier González-García, Macario Martínez-Castillo, Tania Allin Vargas-Pavía, José Manuel Ulloa-Aguilar, Haruki Arévalo-Romero, Guadalupe Léon-Reyes, Addy Cecilia Helguera-Repetto, Julio García-Cordero, Moisés León-Juárez

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.

Original language	English
Pages (from-to)	1177-1182
Number of pages	6
Journal	Archives of Virology
Volume	166
Issue number	4
DOIs	https://doi.org/10.1007/s00705-021-04974-7
State	Published - Apr 2021

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González-García, L. D., Martínez-Castillo, M., Vargas-Pavía, T. A., Ulloa-Aguilar, J. M., Arévalo-Romero, H., Léon-Reyes, G., Helguera-Repetto, A. C., García-Cordero, J., & León-Juárez, M. (2021). Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism. Archives of Virology, 166(4), 1177-1182. https://doi.org/10.1007/s00705-021-04974-7

@article{6476648ce16b4bebbdc15f681d5aac4f,

title = "Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism",

abstract = "Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.",

author = "Gonz{\'a}lez-Garc{\'i}a, {Luis Didier} and Macario Mart{\'i}nez-Castillo and Vargas-Pav{\'i}a, {Tania Allin} and Ulloa-Aguilar, {Jos{\'e} Manuel} and Haruki Ar{\'e}valo-Romero and Guadalupe L{\'e}on-Reyes and Helguera-Repetto, {Addy Cecilia} and Julio Garc{\'i}a-Cordero and Mois{\'e}s Le{\'o}n-Ju{\'a}rez",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, AT part of Springer Nature.",

year = "2021",

month = apr,

doi = "10.1007/s00705-021-04974-7",

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González-García, LD, Martínez-Castillo, M, Vargas-Pavía, TA, Ulloa-Aguilar, JM, Arévalo-Romero, H, Léon-Reyes, G, Helguera-Repetto, AC, García-Cordero, J & León-Juárez, M 2021, 'Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism', Archives of Virology, vol. 166, no. 4, pp. 1177-1182. https://doi.org/10.1007/s00705-021-04974-7

TY - JOUR

T1 - Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

AU - González-García, Luis Didier

AU - Martínez-Castillo, Macario

AU - Vargas-Pavía, Tania Allin

AU - Ulloa-Aguilar, José Manuel

AU - Arévalo-Romero, Haruki

AU - Léon-Reyes, Guadalupe

AU - Helguera-Repetto, Addy Cecilia

AU - García-Cordero, Julio

AU - León-Juárez, Moisés

PY - 2021/4

Y1 - 2021/4

N2 - Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.

AB - Respiratory syncytial virus (RSV) is most commonly associated with upper respiratory tract infections during childhood. The lipid composition of cells and lipogenic enzymes play an important role in RSV infection. There are controversial data about whether lipid biosynthesis regulators such as AMP-activated protein kinase (AMPK) are deregulated by RSV. Hence, we examined whether the activation state of AMPK is altered in RSV-infected HEp-2 cells. Our data show that RSV infection inhibits AMPK activity, favoring the activation of downstream lipogenic effectors and cellular lipid anabolism in HEp-2 cells.

UR - http://www.scopus.com/inward/record.url?scp=85101467503&partnerID=8YFLogxK

U2 - 10.1007/s00705-021-04974-7

DO - 10.1007/s00705-021-04974-7

M3 - Artículo

C2 - 33580381

AN - SCOPUS:85101467503

SN - 0304-8608

VL - 166

SP - 1177

EP - 1182

JO - Archives of Virology

JF - Archives of Virology

IS - 4

ER -

Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism

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