Influence of different types of lactose on tablets compactibility

Karen Alejandra Velázquez González; Eduardo Ramírez Flores; Leopoldo Villafuerte Robles

Influence of different types of lactose on tablets compactibility

Título traducido de la contribución: Influencia de diferentes tipos de lactosa en la compactabilidad de tabletas

Karen Alejandra Velázquez González, Eduardo Ramírez Flores, Leopoldo Villafuerte Robles

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

2 Citas (Scopus)

Resumen

This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D₁₆₂ N = 231) followed by lactose anhydrous NF (D₁₆₂ N = 201), Lactopress anhydrous (D₁₆₂ N = 171) and SuperTab 21AN (D₁₆₂ = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.

Título traducido de la contribución	Influencia de diferentes tipos de lactosa en la compactabilidad de tabletas
Idioma original	Inglés
Páginas (desde-hasta)	41-49
Número de páginas	9
Publicación	Revista Mexicana de Ciencias Farmaceuticas
Volumen	46
N.º	2
Estado	Publicada - 1 abr. 2015

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title = "Influence of different types of lactose on tablets compactibility",

abstract = "This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D162 N = 231) followed by lactose anhydrous NF (D162 N = 201), Lactopress anhydrous (D162 N = 171) and SuperTab 21AN (D162 = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.",

keywords = "Amoxicillin, Captopril, Compactibility, Excipient functionality, Lactose, Tablet hardness, Tablet tensile strength",

author = "{Vel{\'a}zquez Gonz{\'a}lez}, {Karen Alejandra} and {Ram{\'i}rez Flores}, Eduardo and {Villafuerte Robles}, Leopoldo",

year = "2015",

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TY - JOUR

T1 - Influence of different types of lactose on tablets compactibility

AU - Velázquez González, Karen Alejandra

AU - Ramírez Flores, Eduardo

AU - Villafuerte Robles, Leopoldo

PY - 2015/4/1

Y1 - 2015/4/1

N2 - This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D162 N = 231) followed by lactose anhydrous NF (D162 N = 201), Lactopress anhydrous (D162 N = 171) and SuperTab 21AN (D162 = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.

AB - This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D162 N = 231) followed by lactose anhydrous NF (D162 N = 201), Lactopress anhydrous (D162 N = 171) and SuperTab 21AN (D162 = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.

KW - Amoxicillin

KW - Captopril

KW - Compactibility

KW - Excipient functionality

KW - Lactose

KW - Tablet hardness

KW - Tablet tensile strength

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M3 - Artículo

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JO - Revista Mexicana de Ciencias Farmaceuticas

JF - Revista Mexicana de Ciencias Farmaceuticas

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Influence of different types of lactose on tablets compactibility

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