Influence of different types of lactose on tablets compactibility

Karen Alejandra Velázquez González; Eduardo Ramírez Flores; Leopoldo Villafuerte Robles

Influence of different types of lactose on tablets compactibility

Translated title of the contribution: Influence of different types of lactose on tablets compactibility

Karen Alejandra Velázquez González, Eduardo Ramírez Flores, Leopoldo Villafuerte Robles

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D₁₆₂ N = 231) followed by lactose anhydrous NF (D₁₆₂ N = 201), Lactopress anhydrous (D₁₆₂ N = 171) and SuperTab 21AN (D₁₆₂ = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.

Translated title of the contribution	Influence of different types of lactose on tablets compactibility
Original language	English
Pages (from-to)	41-49
Number of pages	9
Journal	Revista Mexicana de Ciencias Farmaceuticas
Volume	46
Issue number	2
State	Published - 1 Apr 2015

Keywords

Amoxicillin
Captopril
Compactibility
Excipient functionality
Lactose
Tablet hardness
Tablet tensile strength

Cite this

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title = "Influence of different types of lactose on tablets compactibility",

abstract = "This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D162 N = 231) followed by lactose anhydrous NF (D162 N = 201), Lactopress anhydrous (D162 N = 171) and SuperTab 21AN (D162 = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.",

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AU - Ramírez Flores, Eduardo

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AB - This study explores the compactibility of SuperTab 24AN compared against SuperTab 21AN, Lactopress anhydrous and lactose anhydrous NF. Individual powders and their mixtures with amoxicillin and captopril are evaluated. Tablets of unlubricated lactose does not allow the perception of a different compactibility. However, with 2% stearic acid is greater the compactibility of SuperTab 24AN (D162 N = 231) followed by lactose anhydrous NF (D162 N = 201), Lactopress anhydrous (D162 N = 171) and SuperTab 21AN (D162 = 123 N). Mixing with the drugs decreases the compactibility of the excipients, preserving the previously observed order. It also shows an equalizing effect; the advantage of a carrier over the other is less noticeable in the mixtures.

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KW - Captopril

KW - Compactibility

KW - Excipient functionality

KW - Lactose

KW - Tablet hardness

KW - Tablet tensile strength

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Influence of different types of lactose on tablets compactibility

Abstract

Keywords

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