In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae

Mariel Valdés-Arellanes; Gerardo Ortega-Hernández; Doralí M. Cervantes-Santos; Michael Joshue Rendón-Barrón; Eduardo Osiris Madrigal-Santillán; José Antonio Morales-González; Rogelio Paniagua-Pérez; Eduardo Madrigal-Bujaidar; Isela Álvarez-González

doi:10.1080/15569543.2021.1975752

In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae

Mariel Valdés-Arellanes, Gerardo Ortega-Hernández, Doralí M. Cervantes-Santos, Michael Joshue Rendón-Barrón, Eduardo Osiris Madrigal-Santillán, José Antonio Morales-González, Rogelio Paniagua-Pérez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González

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Resumen

The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.

Idioma original	Inglés
Páginas (desde-hasta)	1115-1123
Número de páginas	9
Publicación	Toxin Reviews
Volumen	41
N.º	4
DOI	https://doi.org/10.1080/15569543.2021.1975752
Estado	Publicada - 2022

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Valdés-Arellanes, M., Ortega-Hernández, G., Cervantes-Santos, D. M., Rendón-Barrón, M. J., Madrigal-Santillán, E. O., Morales-González, J. A., Paniagua-Pérez, R., Madrigal-Bujaidar, E., & Álvarez-González, I. (2022). In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae. Toxin Reviews, 41(4), 1115-1123. https://doi.org/10.1080/15569543.2021.1975752

@article{ae8f75717d9947c699a0d56c9870d42a,

title = " In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae",

abstract = "The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.",

keywords = "Mexican serpents, Ophryacus; micronuclei, bone marrow proliferation, mouse",

author = "Mariel Vald{\'e}s-Arellanes and Gerardo Ortega-Hern{\'a}ndez and Cervantes-Santos, {Doral{\'i} M.} and Rend{\'o}n-Barr{\'o}n, {Michael Joshue} and Madrigal-Santill{\'a}n, {Eduardo Osiris} and Morales-Gonz{\'a}lez, {Jos{\'e} Antonio} and Rogelio Paniagua-P{\'e}rez and Eduardo Madrigal-Bujaidar and Isela {\'A}lvarez-Gonz{\'a}lez",

note = "Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/15569543.2021.1975752",

language = "Ingl{\'e}s",

volume = "41",

pages = "1115--1123",

journal = "Toxin Reviews",

issn = "1556-9543",

publisher = "Informa Healthcare",

number = "4",

}

Valdés-Arellanes, M, Ortega-Hernández, G, Cervantes-Santos, DM, Rendón-Barrón, MJ, Madrigal-Santillán, EO , Morales-González, JA, Paniagua-Pérez, R, Madrigal-Bujaidar, E & Álvarez-González, I 2022, ' In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae', Toxin Reviews, vol. 41, n.º 4, pp. 1115-1123. https://doi.org/10.1080/15569543.2021.1975752

TY - JOUR

T1 - In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae

AU - Valdés-Arellanes, Mariel

AU - Ortega-Hernández, Gerardo

AU - Cervantes-Santos, Doralí M.

AU - Rendón-Barrón, Michael Joshue

AU - Madrigal-Santillán, Eduardo Osiris

AU - Morales-González, José Antonio

AU - Paniagua-Pérez, Rogelio

AU - Madrigal-Bujaidar, Eduardo

AU - Álvarez-González, Isela

PY - 2022

Y1 - 2022

N2 - The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.

AB - The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.

KW - Mexican serpents

KW - Ophryacus; micronuclei

KW - bone marrow proliferation

KW - mouse

UR - http://www.scopus.com/inward/record.url?scp=85115254665&partnerID=8YFLogxK

U2 - 10.1080/15569543.2021.1975752

DO - 10.1080/15569543.2021.1975752

M3 - Artículo

AN - SCOPUS:85115254665

SN - 1556-9543

VL - 41

SP - 1115

EP - 1123

JO - Toxin Reviews

JF - Toxin Reviews

IS - 4

ER -

In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae

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