TY - JOUR
T1 - In vivo genotoxic and cytotoxic evaluation of venom obtained from the species of the snake ophryacus, cope, viperidae
AU - Valdés-Arellanes, Mariel
AU - Ortega-Hernández, Gerardo
AU - Cervantes-Santos, Doralí M.
AU - Rendón-Barrón, Michael Joshue
AU - Madrigal-Santillán, Eduardo Osiris
AU - Morales-González, José Antonio
AU - Paniagua-Pérez, Rogelio
AU - Madrigal-Bujaidar, Eduardo
AU - Álvarez-González, Isela
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.
AB - The present study was made to determine the mouse in vivo micronuclei induction capacity of the venom obtained from three Mexican endemic snakes: Ophryacus undulatus, Ophryacus smaragdinus, and Ophryacus sphenophrys. A second aim was to determine their capacity to induce bone marrow cytotoxicity in the same animals. Results obtained in mouse peripheral blood showed that O. undulatus venom moderately increased the number of micronuclei and produced cytotoxic damage. The venom of O. smaragdinus was also a moderate micronuclei and cytotoxic inducer, and the venom of O. sphenophrys showed neither genotoxic nor cytotoxic effect.
KW - Mexican serpents
KW - Ophryacus; micronuclei
KW - bone marrow proliferation
KW - mouse
UR - http://www.scopus.com/inward/record.url?scp=85115254665&partnerID=8YFLogxK
U2 - 10.1080/15569543.2021.1975752
DO - 10.1080/15569543.2021.1975752
M3 - Artículo
AN - SCOPUS:85115254665
SN - 1556-9543
VL - 41
SP - 1115
EP - 1123
JO - Toxin Reviews
JF - Toxin Reviews
IS - 4
ER -