Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine

Marlet Martinez-Archundia; José Correa Basurto; Jazmín García Machorro; L. Ramírez Salinas Gema

Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine

Título traducido de la contribución: Estudio inmunoinformatico para la busqueda de epitopes dirigidos a la glicoproteina espiga de SARS-CoV2 como vacuna potencial

Marlet Martinez-Archundia, José Correa Basurto, Jazmín García Machorro, L. Ramírez Salinas Gema

Escuela Superior de Medicina (ESM)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Resumen

The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein).

Título traducido de la contribución	Estudio inmunoinformatico para la busqueda de epitopes dirigidos a la glicoproteina espiga de SARS-CoV2 como vacuna potencial
Idioma original	Inglés
Páginas (desde-hasta)	1
Número de páginas	14
Publicación	Journal of Biomolecular Structure and Dynamics
Estado	Publicada - 25 jun. 2020

Palabras clave

immunoinformatics
epitopes
spike protein

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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abstract = "The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein). ",

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AU - Martinez-Archundia, Marlet

AU - Correa Basurto, José

AU - García Machorro, Jazmín

AU - Gema, L. Ramírez Salinas

PY - 2020/6/25

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AB - The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein).

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KW - epitopes

KW - spike protein

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JF - Journal of Biomolecular Structure and Dynamics

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