Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine

Marlet Martinez-Archundia; José Correa Basurto; Jazmín García Machorro; L. Ramírez Salinas Gema

Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine

Marlet Martinez-Archundia, José Correa Basurto, Jazmín García Machorro, L. Ramírez Salinas Gema

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

Abstract

The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein).

Translated title of the contribution	Estudio inmunoinformatico para la busqueda de epitopes dirigidos a la glicoproteina espiga de SARS-CoV2 como vacuna potencial
Original language	English
Pages (from-to)	1
Number of pages	14
Journal	Journal of Biomolecular Structure and Dynamics
State	Published - 25 Jun 2020

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Cite this

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title = "Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine",

abstract = "The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein). ",

keywords = "immunoinformatics, epitopes, spike protein",

author = "Marlet Martinez-Archundia and {Correa Basurto}, Jos{\'e} and {Garc{\'i}a Machorro}, Jazm{\'i}n and Gema, {L. Ram{\'i}rez Salinas}",

year = "2020",

month = jun,

day = "25",

language = "Ingl{\'e}s",

pages = "1",

journal = "Journal of Biomolecular Structure and Dynamics",

issn = "0739-1102",

publisher = "Taylor and Francis Ltd.",

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T1 - Immunoinformatics study to search epitopes of spike glycoprotein from SARS-CoV-2 as potential vaccine

AU - Martinez-Archundia, Marlet

AU - Correa Basurto, José

AU - García Machorro, Jazmín

AU - Gema, L. Ramírez Salinas

PY - 2020/6/25

Y1 - 2020/6/25

N2 - The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein).

AB - The Coronavirus disease named COVID-19 is caused by the virus reported in 2019 first identified in China. The cases of this disease have increased and as of June 1st, 2020 there are more than 216 countries affected. Pharmacological treatments have been proposed based on the resemblance of the HIV virus. With regard to prevention there is no vaccine, thus, we proposed to explore the spike protein due to its presence on the viral surface, and it also contains the putative viral entry receptor as well as the fusion peptide (important in the genome release). In this work we have employed In Silico techniques such as immunoinformatics tools which permit the identification of potential immunogenic regions on the viral surface (spike glycoprotein).

KW - immunoinformatics

KW - epitopes

KW - spike protein

M3 - Artículo

SN - 0739-1102

SP - 1

JO - Journal of Biomolecular Structure and Dynamics

JF - Journal of Biomolecular Structure and Dynamics

ER -