Exact critical values for farrington-manning noninferiority exact test

David Sotres-Ramos, Félix Almendra-Arao, Cecilia Ramírez-Figueroa

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Noninferiority tests are frequently used in clinical trials to demonstrate that a new therapy, with minimum side effects or low cost, is not significantly inferior in efficacy to the standard therapy. The exact version of the Farrington-Manning noninferiority test for two independent binomial proportions has been studied and recommended by several authors. However, this exact test is difficult to apply because the critical constant and the size of the test are complicated to calculate. To facilitate the use of the Farrington-Manning exact test, a computer program has been written in SPLUS 2000, which calculates the critical constant and the size of this test. Also, it has been verified that this test is not very conservative. Copyright © 2010 Drug Information Association, Inc. All rights reserved.
Idioma originalInglés estadounidense
Páginas (desde-hasta)159-164
Número de páginas142
PublicaciónDrug Information Journal
DOI
EstadoPublicada - 1 ene 2010

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