Exact critical values for farrington-manning noninferiority exact test

Noninferiority tests are frequently used in clinical trials to demonstrate that a new therapy, with minimum side effects or low cost, is not significantly inferior in efficacy to the standard therapy. The exact version of the Farrington-Manning noninferiority test for two independent binomial proportions has been studied and recommended by several authors. However, this exact test is difficult to apply because the critical constant and the size of the test are complicated to calculate. To facilitate the use of the Farrington-Manning exact test, a computer program has been written in SPLUS 2000, which calculates the critical constant and the size of this test. Also, it has been verified that this test is not very conservative.