TY - JOUR
T1 - Exact critical values for farrington-manning noninferiority exact test
AU - Sotres-Ramos, David
AU - Almendra-Arao, Félix
AU - Ramírez-Figueroa, Cecilia
PY - 2010/3
Y1 - 2010/3
N2 - Noninferiority tests are frequently used in clinical trials to demonstrate that a new therapy, with minimum side effects or low cost, is not significantly inferior in efficacy to the standard therapy. The exact version of the Farrington-Manning noninferiority test for two independent binomial proportions has been studied and recommended by several authors. However, this exact test is difficult to apply because the critical constant and the size of the test are complicated to calculate. To facilitate the use of the Farrington-Manning exact test, a computer program has been written in SPLUS 2000, which calculates the critical constant and the size of this test. Also, it has been verified that this test is not very conservative.
AB - Noninferiority tests are frequently used in clinical trials to demonstrate that a new therapy, with minimum side effects or low cost, is not significantly inferior in efficacy to the standard therapy. The exact version of the Farrington-Manning noninferiority test for two independent binomial proportions has been studied and recommended by several authors. However, this exact test is difficult to apply because the critical constant and the size of the test are complicated to calculate. To facilitate the use of the Farrington-Manning exact test, a computer program has been written in SPLUS 2000, which calculates the critical constant and the size of this test. Also, it has been verified that this test is not very conservative.
KW - Exact test
KW - Farrington-Manning
KW - Noninferiority
KW - Size of a test
UR - http://www.scopus.com/inward/record.url?scp=77954950478&partnerID=8YFLogxK
U2 - 10.1177/009286151004400207
DO - 10.1177/009286151004400207
M3 - Artículo
SN - 0092-8615
VL - 44
SP - 159
EP - 164
JO - Drug Information Journal
JF - Drug Information Journal
IS - 2
ER -