El ácido valproico como agente sensibilizador al tratamiento anticáncer

Gabriela Rebeca Luna-Palencia; José Correa-Basurto; Ismael Vásquez-Moctezuma

doi:10.24875/GMM.18004759

El ácido valproico como agente sensibilizador al tratamiento anticáncer

Gabriela Rebeca Luna-Palencia, José Correa-Basurto, Ismael Vásquez-Moctezuma

Escuela Superior de Medicina (ESM)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.

Título traducido de la contribución	Valproic acid as an anticancer treatment sensitizing agent
Idioma original	Español
Páginas (desde-hasta)	417-422
Número de páginas	6
Publicación	Gaceta Medica de Mexico
Volumen	155
N.º	4
DOI	https://doi.org/10.24875/GMM.18004759
Estado	Publicada - 1 jul. 2019

Palabras clave

Epigenetic therapy
Histone deacetylase inhibitors
Human cancer therapy
Valproic acid

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abstract = "Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.",

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AU - Luna-Palencia, Gabriela Rebeca

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AU - Vásquez-Moctezuma, Ismael

PY - 2019/7/1

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N2 - Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.

AB - Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.

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El ácido valproico como agente sensibilizador al tratamiento anticáncer

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