TY - JOUR
T1 - El ácido valproico como agente sensibilizador al tratamiento anticáncer
AU - Luna-Palencia, Gabriela Rebeca
AU - Correa-Basurto, José
AU - Vásquez-Moctezuma, Ismael
N1 - Publisher Copyright:
© 2019, (publisher Name). All right reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.
AB - Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.
KW - Epigenetic therapy
KW - Histone deacetylase inhibitors
KW - Human cancer therapy
KW - Valproic acid
UR - http://www.scopus.com/inward/record.url?scp=85071771741&partnerID=8YFLogxK
U2 - 10.24875/GMM.18004759
DO - 10.24875/GMM.18004759
M3 - Artículo
C2 - 31486787
AN - SCOPUS:85071771741
SN - 0016-3813
VL - 155
SP - 417
EP - 422
JO - Gaceta Medica de Mexico
JF - Gaceta Medica de Mexico
IS - 4
ER -
