TY - JOUR
T1 - Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)
AU - Valadez-Vega, Carmen
AU - Alvarez-Manilla, Gerardo
AU - Riverón-Negrete, Leticia
AU - García-Carrancá, Alejandro
AU - Morales-González, José A.
AU - Zuniga-Pérez, Clara
AU - Madrigal-Santillán, Eduardo
AU - Esquivel-Soto, Jaime
AU - Esquivel-Chirino, Cesar
AU - Villagómez-Ibarra, Roberto
AU - Bautista, Mirandeli
AU - Morales-González, Ángel
PY - 2011/3
Y1 - 2011/3
N2 - Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
AB - Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.
KW - Cytotoxicity
KW - Lectins
KW - Tepary bean lectins
KW - Tepary beans
UR - http://www.scopus.com/inward/record.url?scp=79953080396&partnerID=8YFLogxK
U2 - 10.3390/molecules16032107
DO - 10.3390/molecules16032107
M3 - Artículo
C2 - 21368722
AN - SCOPUS:79953080396
SN - 1420-3049
VL - 16
SP - 2107
EP - 2118
JO - Molecules
JF - Molecules
IS - 3
ER -