Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)

Carmen Valadez-Vega; Gerardo Alvarez-Manilla; Leticia Riverón-Negrete; Alejandro García-Carrancá; José A. Morales-González; Clara Zuniga-Pérez; Eduardo Madrigal-Santillán; Jaime Esquivel-Soto; Cesar Esquivel-Chirino; Roberto Villagómez-Ibarra; Mirandeli Bautista; Ángel Morales-González

doi:10.3390/molecules16032107

Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)

Carmen Valadez-Vega, Gerardo Alvarez-Manilla, Leticia Riverón-Negrete, Alejandro García-Carrancá, José A. Morales-González, Clara Zuniga-Pérez, Eduardo Madrigal-Santillán, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Roberto Villagómez-Ibarra, Mirandeli Bautista, Ángel Morales-González

Escuela Superior de Cómputo (ESCOM)

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.

Original language	English
Pages (from-to)	2107-2118
Number of pages	12
Journal	Molecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/molecules16032107
State	Published - Mar 2011

Keywords

Cytotoxicity
Lectins
Tepary bean lectins
Tepary beans

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10.3390/molecules16032107

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Valadez-Vega, C., Alvarez-Manilla, G., Riverón-Negrete, L., García-Carrancá, A., Morales-González, J. A., Zuniga-Pérez, C., Madrigal-Santillán, E., Esquivel-Soto, J., Esquivel-Chirino, C., Villagómez-Ibarra, R., Bautista, M., & Morales-González, Á. (2011). Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A). Molecules, 16(3), 2107-2118. https://doi.org/10.3390/molecules16032107

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title = "Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)",

abstract = "Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.",

keywords = "Cytotoxicity, Lectins, Tepary bean lectins, Tepary beans",

author = "Carmen Valadez-Vega and Gerardo Alvarez-Manilla and Leticia River{\'o}n-Negrete and Alejandro Garc{\'i}a-Carranc{\'a} and Morales-Gonz{\'a}lez, {Jos{\'e} A.} and Clara Zuniga-P{\'e}rez and Eduardo Madrigal-Santill{\'a}n and Jaime Esquivel-Soto and Cesar Esquivel-Chirino and Roberto Villag{\'o}mez-Ibarra and Mirandeli Bautista and {\'A}ngel Morales-Gonz{\'a}lez",

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Valadez-Vega, C, Alvarez-Manilla, G, Riverón-Negrete, L, García-Carrancá, A, Morales-González, JA, Zuniga-Pérez, C, Madrigal-Santillán, E, Esquivel-Soto, J, Esquivel-Chirino, C, Villagómez-Ibarra, R, Bautista, M & Morales-González, Á 2011, 'Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)', Molecules, vol. 16, no. 3, pp. 2107-2118. https://doi.org/10.3390/molecules16032107

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T1 - Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)

AU - Valadez-Vega, Carmen

AU - Alvarez-Manilla, Gerardo

AU - Riverón-Negrete, Leticia

AU - García-Carrancá, Alejandro

AU - Morales-González, José A.

AU - Zuniga-Pérez, Clara

AU - Madrigal-Santillán, Eduardo

AU - Esquivel-Soto, Jaime

AU - Esquivel-Chirino, Cesar

AU - Villagómez-Ibarra, Roberto

AU - Bautista, Mirandeli

AU - Morales-González, Ángel

PY - 2011/3

Y1 - 2011/3

N2 - Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.

AB - Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.

KW - Cytotoxicity

KW - Lectins

KW - Tepary bean lectins

KW - Tepary beans

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U2 - 10.3390/molecules16032107

DO - 10.3390/molecules16032107

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AN - SCOPUS:79953080396

SN - 1420-3049

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SP - 2107

EP - 2118

JO - Molecules

JF - Molecules

IS - 3

ER -

Detection of cytotoxic activity of lectin on human colon adenocarcinoma (Sw480) and epithelial cervical carcinoma (C33-A)

Abstract

Keywords

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