Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis

J. L. González-Solís; J. Rodríguez-López; J. C. Martínez-Espinosa; C. Frausto-Reyes; L. F. Jave-Suárez; A. C. Aguilar-Lemarroy; H. Vargas-Rodríguez; E. Martínez-Cano

doi:10.1063/1.3453792

Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis

J. L. González-Solís, J. Rodríguez-López, J. C. Martínez-Espinosa, C. Frausto-Reyes, L. F. Jave-Suárez, A. C. Aguilar-Lemarroy, H. Vargas-Rodríguez, E. Martínez-Cano

Producción científica: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

17 Citas (Scopus)

Resumen

The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. The blood samples were obtained from 20 patients who were clinically diagnosed with cervical cancer and 10 healthy volunteer. The imprint was put under the Olympus microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with NIR 830 nm laser. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated when the multivariate statistical methods of Principal Component Analysis (PCA) and Linear Discriminated Analysis (LDA) is applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be a new technique for the detection using just blood samples.

Idioma original	Inglés
Título de la publicación alojada	Laser Florence 2009
Subtítulo de la publicación alojada	A Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress
Páginas	91-95
Número de páginas	5
DOI	https://doi.org/10.1063/1.3453792
Estado	Publicada - 2010
Publicado de forma externa	Sí
Evento	Congress of the International Academy Laser Medicine and Surgery - Firenze, Italia Duración: 6 nov. 2009 → 7 nov. 2009

Serie de la publicación

Nombre	AIP Conference Proceedings
Volumen	1226
ISSN (versión impresa)	0094-243X
ISSN (versión digital)	1551-7616

Conferencia

Conferencia	Congress of the International Academy Laser Medicine and Surgery
País/Territorio	Italia
Ciudad	Firenze
Período	6/11/09 → 7/11/09

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González-Solís, J. L., Rodríguez-López, J., Martínez-Espinosa, J. C., Frausto-Reyes, C., Jave-Suárez, L. F., Aguilar-Lemarroy, A. C., Vargas-Rodríguez, H., & Martínez-Cano, E. (2010). Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis. En Laser Florence 2009: A Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress (pp. 91-95). (AIP Conference Proceedings; Vol. 1226). https://doi.org/10.1063/1.3453792

@inproceedings{a088cffdf750460890f5012caead1cce,

title = "Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis",

abstract = "The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. The blood samples were obtained from 20 patients who were clinically diagnosed with cervical cancer and 10 healthy volunteer. The imprint was put under the Olympus microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with NIR 830 nm laser. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated when the multivariate statistical methods of Principal Component Analysis (PCA) and Linear Discriminated Analysis (LDA) is applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be a new technique for the detection using just blood samples.",

keywords = "Cervical cancer, Multivariate analysis, Raman spectroscopy, Serum",

author = "Gonz{\'a}lez-Sol{\'i}s, {J. L.} and J. Rodr{\'i}guez-L{\'o}pez and Mart{\'i}nez-Espinosa, {J. C.} and C. Frausto-Reyes and Jave-Su{\'a}rez, {L. F.} and Aguilar-Lemarroy, {A. C.} and H. Vargas-Rodr{\'i}guez and E. Mart{\'i}nez-Cano",

year = "2010",

doi = "10.1063/1.3453792",

language = "Ingl{\'e}s",

isbn = "9780735407701",

series = "AIP Conference Proceedings",

pages = "91--95",

booktitle = "Laser Florence 2009",

note = "Congress of the International Academy Laser Medicine and Surgery ; Conference date: 06-11-2009 Through 07-11-2009",

}

González-Solís, JL, Rodríguez-López, J, Martínez-Espinosa, JC, Frausto-Reyes, C, Jave-Suárez, LF, Aguilar-Lemarroy, AC, Vargas-Rodríguez, H & Martínez-Cano, E 2010, Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis. En Laser Florence 2009: A Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress. AIP Conference Proceedings, vol. 1226, pp. 91-95, Congress of the International Academy Laser Medicine and Surgery, Firenze, Italia, 6/11/09. https://doi.org/10.1063/1.3453792

Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis. / González-Solís, J. L.; Rodríguez-López, J.; Martínez-Espinosa, J. C. et al.
Laser Florence 2009: A Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress. 2010. p. 91-95 (AIP Conference Proceedings; Vol. 1226).

Producción científica: Capítulo del libro/informe/acta de congreso › Contribución a la conferencia › revisión exhaustiva

TY - GEN

T1 - Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis

AU - González-Solís, J. L.

AU - Rodríguez-López, J.

AU - Martínez-Espinosa, J. C.

AU - Frausto-Reyes, C.

AU - Jave-Suárez, L. F.

AU - Aguilar-Lemarroy, A. C.

AU - Vargas-Rodríguez, H.

AU - Martínez-Cano, E.

PY - 2010

Y1 - 2010

N2 - The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. The blood samples were obtained from 20 patients who were clinically diagnosed with cervical cancer and 10 healthy volunteer. The imprint was put under the Olympus microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with NIR 830 nm laser. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated when the multivariate statistical methods of Principal Component Analysis (PCA) and Linear Discriminated Analysis (LDA) is applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be a new technique for the detection using just blood samples.

AB - The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. The blood samples were obtained from 20 patients who were clinically diagnosed with cervical cancer and 10 healthy volunteer. The imprint was put under the Olympus microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with NIR 830 nm laser. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated when the multivariate statistical methods of Principal Component Analysis (PCA) and Linear Discriminated Analysis (LDA) is applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be a new technique for the detection using just blood samples.

KW - Cervical cancer

KW - Multivariate analysis

KW - Raman spectroscopy

KW - Serum

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U2 - 10.1063/1.3453792

DO - 10.1063/1.3453792

M3 - Contribución a la conferencia

AN - SCOPUS:77954575236

SN - 9780735407701

T3 - AIP Conference Proceedings

SP - 91

EP - 95

BT - Laser Florence 2009

T2 - Congress of the International Academy Laser Medicine and Surgery

Y2 - 6 November 2009 through 7 November 2009

ER -

González-Solís JL, Rodríguez-López J, Martínez-Espinosa JC, Frausto-Reyes C, Jave-Suárez LF, Aguilar-Lemarroy AC et al. Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis. En Laser Florence 2009: A Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress. 2010. p. 91-95. (AIP Conference Proceedings). doi: 10.1063/1.3453792

Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis

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