Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis

J. L. González-Solís, J. Rodríguez-López, J. C. Martínez-Espinosa, C. Frausto-Reyes, L. F. Jave-Suárez, A. C. Aguilar-Lemarroy, H. Vargas-Rodríguez, E. Martínez-Cano

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

17 Scopus citations

Abstract

The use of Raman spectroscopy to analyze blood biochemistry and hence distinguish between normal and abnormal blood was investigated. The blood samples were obtained from 20 patients who were clinically diagnosed with cervical cancer and 10 healthy volunteer. The imprint was put under the Olympus microscope and several points were chosen for Raman measurement. All spectra were collected at a Jobin-Yvon LabRAM HR800 Raman Spectrometer with NIR 830 nm laser. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated when the multivariate statistical methods of Principal Component Analysis (PCA) and Linear Discriminated Analysis (LDA) is applied to their Raman spectra. The ratios of some band intensities were analyzed and some band ratios were significant and corresponded to proteins, phospholipids, and polysaccharides. The preliminary results suggest that Raman spectroscopy could be a new technique for the detection using just blood samples.

Original languageEnglish
Title of host publicationLaser Florence 2009
Subtitle of host publicationA Gallery Through the Laser Medicine World - Selected Papers at the International Laser Medicine Congress
Pages91-95
Number of pages5
DOIs
StatePublished - 2010
Externally publishedYes
EventCongress of the International Academy Laser Medicine and Surgery - Firenze, Italy
Duration: 6 Nov 20097 Nov 2009

Publication series

NameAIP Conference Proceedings
Volume1226
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceCongress of the International Academy Laser Medicine and Surgery
Country/TerritoryItaly
CityFirenze
Period6/11/097/11/09

Keywords

  • Cervical cancer
  • Multivariate analysis
  • Raman spectroscopy
  • Serum

Fingerprint

Dive into the research topics of 'Detection of cervical cancer analyzing blood samples with Raman spectroscopy and multivariate analysis'. Together they form a unique fingerprint.

Cite this