TY - JOUR
T1 - Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum
T2 - Role of nitric oxide, prostaglandins and sulfydryls
AU - Sánchez-Mendoza, María Elena
AU - Reyes-Trejo, Benito
AU - Sánchez-Gómez, Paula
AU - Rodríguez-Silverio, Juan
AU - Castillo-Henkel, Carlos
AU - Cervantes-Cuevas, Humberto
AU - Arrieta, Jesús
N1 - Funding Information:
This work was suported by grant from the Escuela Superior de Medicina del Instituto Politécnico Nacional (México) (Proyecto 20082383 ). We thank Bruce Allan Larsen for reviewing the use of English in this manuscript.
PY - 2010/1
Y1 - 2010/1
N2 - Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by NG-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.
AB - Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by NG-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.
KW - Asteraceae
KW - Encecanescin
KW - Eupatorium aschenbornianum
KW - Gastroprotection
KW - Peptic ulcer
UR - http://www.scopus.com/inward/record.url?scp=70450224472&partnerID=8YFLogxK
U2 - 10.1016/j.fitote.2009.07.009
DO - 10.1016/j.fitote.2009.07.009
M3 - Artículo
SN - 0367-326X
VL - 81
SP - 66
EP - 71
JO - Fitoterapia
JF - Fitoterapia
IS - 1
ER -