Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: Role of nitric oxide, prostaglandins and sulfydryls

María Elena Sánchez-Mendoza; Benito Reyes-Trejo; Paula Sánchez-Gómez; Juan Rodríguez-Silverio; Carlos Castillo-Henkel; Humberto Cervantes-Cuevas; Jesús Arrieta

doi:10.1016/j.fitote.2009.07.009

Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: Role of nitric oxide, prostaglandins and sulfydryls

María Elena Sánchez-Mendoza, Benito Reyes-Trejo, Paula Sánchez-Gómez, Juan Rodríguez-Silverio, Carlos Castillo-Henkel, Humberto Cervantes-Cuevas, Jesús Arrieta

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by N^G-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.

Original language	English
Pages (from-to)	66-71
Number of pages	6
Journal	Fitoterapia
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/j.fitote.2009.07.009
State	Published - Jan 2010

Keywords

Asteraceae
Encecanescin
Eupatorium aschenbornianum
Gastroprotection
Peptic ulcer

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10.1016/j.fitote.2009.07.009

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title = "Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: Role of nitric oxide, prostaglandins and sulfydryls",

abstract = "Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by NG-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.",

keywords = "Asteraceae, Encecanescin, Eupatorium aschenbornianum, Gastroprotection, Peptic ulcer",

author = "S{\'a}nchez-Mendoza, {Mar{\'i}a Elena} and Benito Reyes-Trejo and Paula S{\'a}nchez-G{\'o}mez and Juan Rodr{\'i}guez-Silverio and Carlos Castillo-Henkel and Humberto Cervantes-Cuevas and Jes{\'u}s Arrieta",

note = "Funding Information: This work was suported by grant from the Escuela Superior de Medicina del Instituto Polit{\'e}cnico Nacional (M{\'e}xico) (Proyecto 20082383 ). We thank Bruce Allan Larsen for reviewing the use of English in this manuscript.",

year = "2010",

month = jan,

doi = "10.1016/j.fitote.2009.07.009",

language = "Ingl{\'e}s",

volume = "81",

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journal = "Fitoterapia",

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T1 - Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum

T2 - Role of nitric oxide, prostaglandins and sulfydryls

AU - Sánchez-Mendoza, María Elena

AU - Reyes-Trejo, Benito

AU - Sánchez-Gómez, Paula

AU - Rodríguez-Silverio, Juan

AU - Castillo-Henkel, Carlos

AU - Cervantes-Cuevas, Humberto

AU - Arrieta, Jesús

N1 - Funding Information: This work was suported by grant from the Escuela Superior de Medicina del Instituto Politécnico Nacional (México) (Proyecto 20082383 ). We thank Bruce Allan Larsen for reviewing the use of English in this manuscript.

PY - 2010/1

Y1 - 2010/1

N2 - Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by NG-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.

AB - Eupatorium aschenbornianum is considered useful in the treatment of gastric ulcer. In the current study the validity of this practice was tested by using the experimental model of an ethanol induced gastric ulcer in rats. The results show that E. aschenbornianum had gastroprotective activity, that the hexane extract had the highest protective activity (85.65 ± 4.76%), and that encecanescin isolated from this extract was the main active gastroprotective agent. The effect elicited by encecanescin was attenuated by NG-nitro-l-arginine methyl ester, N-ethylmaleimide and indomethacin, which suggests that NO, prostaglandins and sulfydryl groups are involved in the mechanisms of gastroprotective action.

KW - Asteraceae

KW - Encecanescin

KW - Eupatorium aschenbornianum

KW - Gastroprotection

KW - Peptic ulcer

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U2 - 10.1016/j.fitote.2009.07.009

DO - 10.1016/j.fitote.2009.07.009

M3 - Artículo

SN - 0367-326X

VL - 81

SP - 66

EP - 71

JO - Fitoterapia

JF - Fitoterapia

IS - 1

ER -

Bioassay-guided isolation of an anti-ulcer chromene from Eupatorium aschenbornianum: Role of nitric oxide, prostaglandins and sulfydryls

Abstract

Keywords

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