Resumen
A novel hydroxyapatite-based hybrid material with controlled porosity was designed as a bio-package to implant micro-electro-mechanical systems (MEMS) in living organisms. The biomaterial was prepared using synthetic stoichiometric hydroxyapatite powder reacted with a chemical-active, solvent-free, alkyd-based polyurethane. This porous material has interconnected pores with sizes between 100 and 350 μm and a pore volume fraction of 50%, fulfilling the requirements for implants. The biomaterial additionally has high wearing resistance and hydrolytic stability providing high endurance properties. The bio-package was characterized mechanically and morphologically using X-ray diffraction, scanning electron microscopy, densitometry, abrasion and mechanical tests. Twelve packaged micro-electro-mechanical systems were implanted subcutaneously into rats and tested for up to 9 months with good acceptance as revealed by the histological analysis performed on the soft tissue surrounding each implant.
Idioma original | Inglés |
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Páginas (desde-hasta) | 31-44 |
Número de páginas | 14 |
Publicación | Journal of Biomaterials Science, Polymer Edition |
Volumen | 24 |
N.º | 1 |
DOI | |
Estado | Publicada - 2013 |
Publicado de forma externa | Sí |