Abstract
A novel hydroxyapatite-based hybrid material with controlled porosity was designed as a bio-package to implant micro-electro-mechanical systems (MEMS) in living organisms. The biomaterial was prepared using synthetic stoichiometric hydroxyapatite powder reacted with a chemical-active, solvent-free, alkyd-based polyurethane. This porous material has interconnected pores with sizes between 100 and 350 μm and a pore volume fraction of 50%, fulfilling the requirements for implants. The biomaterial additionally has high wearing resistance and hydrolytic stability providing high endurance properties. The bio-package was characterized mechanically and morphologically using X-ray diffraction, scanning electron microscopy, densitometry, abrasion and mechanical tests. Twelve packaged micro-electro-mechanical systems were implanted subcutaneously into rats and tested for up to 9 months with good acceptance as revealed by the histological analysis performed on the soft tissue surrounding each implant.
| Original language | English |
|---|---|
| Pages (from-to) | 31-44 |
| Number of pages | 14 |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
Keywords
- Bio-package
- Biomaterial
- Hybrid material
- Hydroxyapatite
- Implant
- MEMS
- Transponder