Resumen
A practical and efficient two-step synthesis of N-substituted isoindolin-1-ones was developed. The one-pot reaction of 2-formylbenzoic acid with amines and dimethyl phosphite proceeds in short time either with conventional heating or microwave irradiation under catalyst-free conditions to afford the corresponding N-substituted dimethyl 3-oxoisoindolin-1-ylphosphonates in good yield which, by means of a dephosphonylation reaction with lithium aluminum hydride, give the target N-substituted isoindolin-1-ones in moderate to good yield.
Idioma original | Inglés |
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Páginas (desde-hasta) | 569-574 |
Número de páginas | 6 |
Publicación | Synthesis (Germany) |
Volumen | 44 |
N.º | 4 |
DOI | |
Estado | Publicada - 2012 |
Publicado de forma externa | Sí |