Abstract
A practical and efficient two-step synthesis of N-substituted isoindolin-1-ones was developed. The one-pot reaction of 2-formylbenzoic acid with amines and dimethyl phosphite proceeds in short time either with conventional heating or microwave irradiation under catalyst-free conditions to afford the corresponding N-substituted dimethyl 3-oxoisoindolin-1-ylphosphonates in good yield which, by means of a dephosphonylation reaction with lithium aluminum hydride, give the target N-substituted isoindolin-1-ones in moderate to good yield.
Original language | English |
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Pages (from-to) | 569-574 |
Number of pages | 6 |
Journal | Synthesis (Germany) |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Keywords
- C-P cleavage
- amino phosphonates
- isoindolinones
- microwave irradiation
- one-pot reaction