TY - JOUR
T1 - An antibacterial sesquiterpene lactone from fresh-water alga Vaucheria sessilis
AU - Pérez Gutiérrez, Rosa Martha
PY - 2009/7
Y1 - 2009/7
N2 - A sesquiterpene lactone 10β-Hydroxy-11βH-guai-12,6α-olide has been isolated from hexane extract of fresh-water alga Vaucheria sessilis using bioassay-guided fractionation. Its structure was established by a combination of spectroscopic methods and chemical correlation. The sesquiterpene lactone was assayed against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Vibrio cholerae, Salmonella typhi and Kiebsiella pneumoniae. Disk-diffusion and the macrodilution methods were used as assay. The isolated compound inhibits growth of B. subtilis, B. cereus, E. coli, S. aureus and S. epidermidis in vitro with at a minimun inhibitory concentration (MIC) ranging from 25 to 50 μg/mL. It had no activity at 100 μg/mL against other bacterial species.
AB - A sesquiterpene lactone 10β-Hydroxy-11βH-guai-12,6α-olide has been isolated from hexane extract of fresh-water alga Vaucheria sessilis using bioassay-guided fractionation. Its structure was established by a combination of spectroscopic methods and chemical correlation. The sesquiterpene lactone was assayed against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Vibrio cholerae, Salmonella typhi and Kiebsiella pneumoniae. Disk-diffusion and the macrodilution methods were used as assay. The isolated compound inhibits growth of B. subtilis, B. cereus, E. coli, S. aureus and S. epidermidis in vitro with at a minimun inhibitory concentration (MIC) ranging from 25 to 50 μg/mL. It had no activity at 100 μg/mL against other bacterial species.
KW - Antimicrobial activity
KW - Sesquiterpene lactone
KW - Vaucheria sessilis
UR - http://www.scopus.com/inward/record.url?scp=77749301378&partnerID=8YFLogxK
M3 - Artículo
SN - 0717-7917
VL - 8
SP - 289
EP - 294
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
IS - 4
ER -