Abstract
A sesquiterpene lactone 10β-Hydroxy-11βH-guai-12,6α-olide has been isolated from hexane extract of fresh-water alga Vaucheria sessilis using bioassay-guided fractionation. Its structure was established by a combination of spectroscopic methods and chemical correlation. The sesquiterpene lactone was assayed against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Vibrio cholerae, Salmonella typhi and Kiebsiella pneumoniae. Disk-diffusion and the macrodilution methods were used as assay. The isolated compound inhibits growth of B. subtilis, B. cereus, E. coli, S. aureus and S. epidermidis in vitro with at a minimun inhibitory concentration (MIC) ranging from 25 to 50 μg/mL. It had no activity at 100 μg/mL against other bacterial species.
| Original language | English |
|---|---|
| Pages (from-to) | 289-294 |
| Number of pages | 6 |
| Journal | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas |
| Volume | 8 |
| Issue number | 4 |
| State | Published - Jul 2009 |
| Externally published | Yes |
Keywords
- Antimicrobial activity
- Sesquiterpene lactone
- Vaucheria sessilis