Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Ruth M. López; María C. Castillo; Jorge S. López; Gustavo Guevara; Pedro López; Enrique F. Castillo

doi:10.3109/10641963.2014.954714

Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Ruth M. López, María C. Castillo, Jorge S. López, Gustavo Guevara, Pedro López, Enrique F. Castillo

Escuela Superior de Medicina (ESM)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

Our aim was to determine whether angiotensin type 2 receptors (AT₂R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT₂R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT₂R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

Idioma original	Inglés
Páginas (desde-hasta)	271-279
Número de páginas	9
Publicación	Clinical and Experimental Hypertension
Volumen	37
N.º	4
DOI	https://doi.org/10.3109/10641963.2014.954714
Estado	Publicada - 1 jul. 2015

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title = "Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation",

abstract = "Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.",

keywords = "AT receptors, Anesthetized rat, Angiotensin II, CGP42112, Carotid pulse pressure, Pressure overload",

author = "L{\'o}pez, {Ruth M.} and Castillo, {Mar{\'i}a C.} and L{\'o}pez, {Jorge S.} and Gustavo Guevara and Pedro L{\'o}pez and Castillo, {Enrique F.}",

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doi = "10.3109/10641963.2014.954714",

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Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation. / López, Ruth M.; Castillo, María C.; López, Jorge S. et al.
En: Clinical and Experimental Hypertension, Vol. 37, N.º 4, 01.07.2015, p. 271-279.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

AU - López, Ruth M.

AU - Castillo, María C.

AU - López, Jorge S.

AU - Guevara, Gustavo

AU - López, Pedro

AU - Castillo, Enrique F.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

AB - Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

KW - AT receptors

KW - Anesthetized rat

KW - Angiotensin II

KW - CGP42112

KW - Carotid pulse pressure

KW - Pressure overload

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U2 - 10.3109/10641963.2014.954714

DO - 10.3109/10641963.2014.954714

M3 - Artículo

C2 - 25271908

SN - 1064-1963

VL - 37

SP - 271

EP - 279

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 4

ER -

Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

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