Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Ruth M. López; María C. Castillo; Jorge S. López; Gustavo Guevara; Pedro López; Enrique F. Castillo

doi:10.3109/10641963.2014.954714

Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Ruth M. López, María C. Castillo, Jorge S. López, Gustavo Guevara, Pedro López, Enrique F. Castillo

Escuela Superior de Medicina (ESM)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Our aim was to determine whether angiotensin type 2 receptors (AT₂R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT₂R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT₂R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

Original language	English
Pages (from-to)	271-279
Number of pages	9
Journal	Clinical and Experimental Hypertension
Volume	37
Issue number	4
DOIs	https://doi.org/10.3109/10641963.2014.954714
State	Published - 1 Jul 2015

Keywords

AT receptors
Anesthetized rat
Angiotensin II
CGP42112
Carotid pulse pressure
Pressure overload

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10.3109/10641963.2014.954714

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title = "Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation",

abstract = "Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.",

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T1 - Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

AU - López, Ruth M.

AU - Castillo, María C.

AU - López, Jorge S.

AU - Guevara, Gustavo

AU - López, Pedro

AU - Castillo, Enrique F.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

AB - Our aim was to determine whether angiotensin type 2 receptors (AT2R) are involved in the depression of carotid pulse pressure (PP) in rats with suprarenal aortic coarctation (SrC). We tested the effects of losartan, PD123319, and CGP42112 on PP in SrC and Sham-operated anesthetized rats. PP increased in SrC rats. Neither losartan nor PD123319 affected PP in SrC and Sham-operated rats. CGP42112 reduced PP, in SrC rats, combined with losartan. Moreover, PD123319 blocked this effect. AT2R protein increased in the thoracic aortas of SrC rats. Thus, upregulated AT2R stimulation by CGP42112 mediates depression of PP in rats under pressure overloading.

KW - AT receptors

KW - Anesthetized rat

KW - Angiotensin II

KW - CGP42112

KW - Carotid pulse pressure

KW - Pressure overload

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DO - 10.3109/10641963.2014.954714

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SN - 1064-1963

VL - 37

SP - 271

EP - 279

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

IS - 4

ER -

Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation

Abstract

Keywords

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