A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia

Edith Fabiola Martínez-Pérez; Eleuterio Burgueño-Tapia; Samuel Roa-Flores; Aranza E. Bendaña-Piñeiro; Eugenio Sánchez-Arreola; Horacio Bach; Luis Ricardo Hernández

doi:10.1080/14786419.2020.1762184

A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia

Edith Fabiola Martínez-Pérez, Eleuterio Burgueño-Tapia, Samuel Roa-Flores, Aranza E. Bendaña-Piñeiro, Eugenio Sánchez-Arreola, Horacio Bach, Luis Ricardo Hernández

Escuela Nacional de Ciencias Biológicas (ENCB)

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.

Idioma original	Inglés
Páginas (desde-hasta)	71-78
Número de páginas	8
Publicación	Natural Product Research
Volumen	36
N.º	1
DOI	https://doi.org/10.1080/14786419.2020.1762184
Estado	Publicada - 2021

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@article{db27b40b2401439db3f267e721a0cd3e,

title = "A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia",

abstract = "The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.",

keywords = "Buddleja marrubiifolia, Scrophulariaceae, anti-inflammatory, antibacterial, antifungal, cytotoxicity, immunomodulatory",

author = "Mart{\'i}nez-P{\'e}rez, {Edith Fabiola} and Eleuterio Burgue{\~n}o-Tapia and Samuel Roa-Flores and Benda{\~n}a-Pi{\~n}eiro, {Aranza E.} and Eugenio S{\'a}nchez-Arreola and Horacio Bach and Hern{\'a}ndez, {Luis Ricardo}",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

doi = "10.1080/14786419.2020.1762184",

language = "Ingl{\'e}s",

volume = "36",

pages = "71--78",

journal = "Natural Product Research",

issn = "1478-6419",

number = "1",

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TY - JOUR

T1 - A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia

AU - Martínez-Pérez, Edith Fabiola

AU - Burgueño-Tapia, Eleuterio

AU - Roa-Flores, Samuel

AU - Bendaña-Piñeiro, Aranza E.

AU - Sánchez-Arreola, Eugenio

AU - Bach, Horacio

AU - Hernández, Luis Ricardo

PY - 2021

Y1 - 2021

N2 - The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.

AB - The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.

KW - Buddleja marrubiifolia

KW - Scrophulariaceae

KW - anti-inflammatory

KW - antibacterial

KW - antifungal

KW - cytotoxicity

KW - immunomodulatory

UR - http://www.scopus.com/inward/record.url?scp=85084363525&partnerID=8YFLogxK

U2 - 10.1080/14786419.2020.1762184

DO - 10.1080/14786419.2020.1762184

M3 - Artículo

C2 - 32375531

AN - SCOPUS:85084363525

SN - 1478-6419

VL - 36

SP - 71

EP - 78

JO - Natural Product Research

JF - Natural Product Research

IS - 1

ER -

A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia

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