A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia

Edith Fabiola Martínez-Pérez, Eleuterio Burgueño-Tapia, Samuel Roa-Flores, Aranza E. Bendaña-Piñeiro, Eugenio Sánchez-Arreola, Horacio Bach, Luis Ricardo Hernández

Research output: Contribution to journalArticlepeer-review


The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.

Original languageEnglish
JournalNatural Product Research
StateAccepted/In press - 2020


  • anti-inflammatory
  • antibacterial
  • antifungal
  • Buddleja marrubiifolia
  • cytotoxicity
  • immunomodulatory
  • Scrophulariaceae


Dive into the research topics of 'A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia'. Together they form a unique fingerprint.

Cite this