TY - JOUR
T1 - A new diterpene and bioactivities of labdanes isolated from Buddleja marrubiifolia
AU - Martínez-Pérez, Edith Fabiola
AU - Burgueño-Tapia, Eleuterio
AU - Roa-Flores, Samuel
AU - Bendaña-Piñeiro, Aranza E.
AU - Sánchez-Arreola, Eugenio
AU - Bach, Horacio
AU - Hernández, Luis Ricardo
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.
AB - The new labdane [(3R*,4aR*,7S*,10aS*,10bR*)-3-ethenyl-3,4a,7,10a-tetramethyl-dodecahydro-1H-naphtho-[2,1-b]-pyran-7-yl]-methylbenzoate together with other 7 labdanes were isolated from the aerial parts of Buddlejamarrubiifolia. Compound structures were elucidated by spectroscopic methods. Some compounds showed moderate to weak antimicrobial activity towards a panel of bacterial and fungal pathogens. In addition, trans-biformene (2) and ribenol acetate (8) showed to be highly cytotoxic with LC50 < 1 µg/mL, the other compounds showed moderate cytotoxic effect with a LC50 range of 6.008–15.26 µg/mL. For all isolated compounds, no inflammatory response was observed.
KW - Buddleja marrubiifolia
KW - Scrophulariaceae
KW - anti-inflammatory
KW - antibacterial
KW - antifungal
KW - cytotoxicity
KW - immunomodulatory
UR - http://www.scopus.com/inward/record.url?scp=85084363525&partnerID=8YFLogxK
U2 - 10.1080/14786419.2020.1762184
DO - 10.1080/14786419.2020.1762184
M3 - Artículo
C2 - 32375531
AN - SCOPUS:85084363525
SN - 1478-6419
VL - 36
SP - 71
EP - 78
JO - Natural Product Research
JF - Natural Product Research
IS - 1
ER -