T3 deficiency prolongs convulsions induced by acute pentylenetetrazole

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The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 μg/kg · day, N = 9) or methimazole (60 mg/kg · day, N = 5) dissolved in drinking water. Compared to controls (N = 7), methimazole treatment reduced T3 levels (45.4±2.0 vs. 33.0±4.8 ng/dl) and increased seizure duration (36.2±22.4 vs. 289.6±24.4 s) and threshold (29.0±vs. 45.5 mg/kg). Thyroxine treatment increased T3 levels (45.4±2.0 vs. 67.7±4.8 ng/dl), but had no significant effect on seizures.

Original languageEnglish
Pages (from-to)577-579
Number of pages3
JournalHormone and Metabolic Research
Issue number11
StatePublished - 1997


  • Pentylenetetrazole
  • Seizures
  • Thyroxine
  • Triiodothyronine


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