TY - JOUR
T1 - T3 deficiency prolongs convulsions induced by acute pentylenetetrazole
AU - Pacheco-Rosado, J.
AU - Quevedo-Corona, L.
AU - Zamudio-Hernández, S. R.
AU - Chambert, C.
PY - 1997
Y1 - 1997
N2 - The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 μg/kg · day, N = 9) or methimazole (60 mg/kg · day, N = 5) dissolved in drinking water. Compared to controls (N = 7), methimazole treatment reduced T3 levels (45.4±2.0 vs. 33.0±4.8 ng/dl) and increased seizure duration (36.2±22.4 vs. 289.6±24.4 s) and threshold (29.0±vs. 45.5 mg/kg). Thyroxine treatment increased T3 levels (45.4±2.0 vs. 67.7±4.8 ng/dl), but had no significant effect on seizures.
AB - The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 μg/kg · day, N = 9) or methimazole (60 mg/kg · day, N = 5) dissolved in drinking water. Compared to controls (N = 7), methimazole treatment reduced T3 levels (45.4±2.0 vs. 33.0±4.8 ng/dl) and increased seizure duration (36.2±22.4 vs. 289.6±24.4 s) and threshold (29.0±vs. 45.5 mg/kg). Thyroxine treatment increased T3 levels (45.4±2.0 vs. 67.7±4.8 ng/dl), but had no significant effect on seizures.
KW - Pentylenetetrazole
KW - Seizures
KW - Thyroxine
KW - Triiodothyronine
UR - http://www.scopus.com/inward/record.url?scp=0031283194&partnerID=8YFLogxK
U2 - 10.1055/s-2007-979104
DO - 10.1055/s-2007-979104
M3 - Artículo
SN - 0018-5043
VL - 29
SP - 577
EP - 579
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
IS - 11
ER -