TY - JOUR
T1 - Toxoplasma gondii
T2 - Effect of maternal infection in the development of lymphoid organs of BALB/c neonates
AU - Cabañas-Cortés, María Asunción
AU - Reyes-Maldonado, Elba
AU - Montiel-Cervantes, Laura
AU - Domínguez-López, María Lilia
AU - Jiménez-Zamudio, Luis
AU - García-Latorre, Ethel
PY - 2009/3
Y1 - 2009/3
N2 - Toxoplasmosis is one of the worldwide parasitic zoonoses. Alterations in the lymphopoietic system are still poorly studied. We analyzed lymphoid organs of BALB/c mice neonates from Toxoplasma gondii-intraperitoneally-infected mothers on 19th day of gestation, with 30 tachyzoites of strain RH. Normal non-infected pregnant females were used as controls. At 7 days after birth, animals were classified as neonates from infected (NIM) and neonates from non-infected mothers (NNIM). Weight of the thymus and number of thymic cells in NIM were decreased, percentage of apoptosis was significantly increased. Decrease in lymphocytes and monocytes and an increase of plasma cells were observed in bone marrow of NIM. Peripheral blood of NIM showed an increase of monocytes and neutrophils and a decrease in lymphocytes. Infection of the mother during the last day of gestation provokes in the neonates changes in the lymphoid organs that could explain survival of 75% of them.
AB - Toxoplasmosis is one of the worldwide parasitic zoonoses. Alterations in the lymphopoietic system are still poorly studied. We analyzed lymphoid organs of BALB/c mice neonates from Toxoplasma gondii-intraperitoneally-infected mothers on 19th day of gestation, with 30 tachyzoites of strain RH. Normal non-infected pregnant females were used as controls. At 7 days after birth, animals were classified as neonates from infected (NIM) and neonates from non-infected mothers (NNIM). Weight of the thymus and number of thymic cells in NIM were decreased, percentage of apoptosis was significantly increased. Decrease in lymphocytes and monocytes and an increase of plasma cells were observed in bone marrow of NIM. Peripheral blood of NIM showed an increase of monocytes and neutrophils and a decrease in lymphocytes. Infection of the mother during the last day of gestation provokes in the neonates changes in the lymphoid organs that could explain survival of 75% of them.
KW - Bone marrow
KW - Maternal infection
KW - Neonates
KW - Thymus
KW - Toxoplasma gondii
UR - http://www.scopus.com/inward/record.url?scp=59849106497&partnerID=8YFLogxK
U2 - 10.1016/j.exppara.2008.11.015
DO - 10.1016/j.exppara.2008.11.015
M3 - Artículo
C2 - 19114038
SN - 0014-4894
VL - 121
SP - 279
EP - 287
JO - Experimental Parasitology
JF - Experimental Parasitology
IS - 3
ER -