Toxoplasma gondii: Effect of maternal infection in the development of lymphoid organs of BALB/c neonates

María Asunción Cabañas-Cortés, Elba Reyes-Maldonado, Laura Montiel-Cervantes, María Lilia Domínguez-López, Luis Jiménez-Zamudio, Ethel García-Latorre

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

4 Citas (Scopus)

Resumen

Toxoplasmosis is one of the worldwide parasitic zoonoses. Alterations in the lymphopoietic system are still poorly studied. We analyzed lymphoid organs of BALB/c mice neonates from Toxoplasma gondii-intraperitoneally-infected mothers on 19th day of gestation, with 30 tachyzoites of strain RH. Normal non-infected pregnant females were used as controls. At 7 days after birth, animals were classified as neonates from infected (NIM) and neonates from non-infected mothers (NNIM). Weight of the thymus and number of thymic cells in NIM were decreased, percentage of apoptosis was significantly increased. Decrease in lymphocytes and monocytes and an increase of plasma cells were observed in bone marrow of NIM. Peripheral blood of NIM showed an increase of monocytes and neutrophils and a decrease in lymphocytes. Infection of the mother during the last day of gestation provokes in the neonates changes in the lymphoid organs that could explain survival of 75% of them.

Idioma originalInglés
Páginas (desde-hasta)279-287
Número de páginas9
PublicaciónExperimental Parasitology
Volumen121
N.º3
DOI
EstadoPublicada - mar. 2009

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