Synthesis and theoretical QSAR study of a naphthalene-androsterone derivative

Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, María López-Ramos, Elodia Garcia-Cervera, Victor Rivero-Rosado

Research output: Contribution to journalArticle

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Abstract

A new naphthalene-androsterone derivative was synthesized by the reaction of naphthalenyl succinate with an androsterone-succinate-ethylenediamine conjugate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. In order to delineate the structural chemical requirements of naphthalene- androsterone some physicochemical descriptors were evaluated. The results showed an increase in the values of these for the naphthalene-androsterone derivative in comparison with naphthalenyl succinate and androsterone-succinate- ethylenediamine. These data suggest a relationship between the evaluated physicochemical parameters and the degree of lipophilicity of the naphthalene-androsterone derivative. Graphical abstract: [Figure not available: see fulltext.] © 2011 Springer-Verlag.
Original languageAmerican English
Pages (from-to)1187-1191
Number of pages1067
JournalMonatshefte fur Chemie
DOIs
StatePublished - 1 Nov 2011
Externally publishedYes

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Androsterone
Quantitative Structure-Activity Relationship
ethylenediamine
Theoretical Models
Succinic Acid
Derivatives
Ethyldimethylaminopropyl Carbodiimide
naphthalene

Cite this

Figueroa-Valverde, Lauro ; Díaz-Cedillo, Francisco ; López-Ramos, María ; Garcia-Cervera, Elodia ; Rivero-Rosado, Victor. / Synthesis and theoretical QSAR study of a naphthalene-androsterone derivative. In: Monatshefte fur Chemie. 2011 ; pp. 1187-1191.
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Synthesis and theoretical QSAR study of a naphthalene-androsterone derivative. / Figueroa-Valverde, Lauro; Díaz-Cedillo, Francisco; López-Ramos, María; Garcia-Cervera, Elodia; Rivero-Rosado, Victor.

In: Monatshefte fur Chemie, 01.11.2011, p. 1187-1191.

Research output: Contribution to journalArticle

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