Synthesis and theoretical QSAR study of a naphthalene-androsterone derivative

Lauro Figueroa-Valverde, Francisco Díaz-Cedillo, María López-Ramos, Elodia Garcia-Cervera, Victor Rivero-Rosado

Resultado de la investigación: Contribución a una revistaArtículo

1 Cita (Scopus)

Resumen

A new naphthalene-androsterone derivative was synthesized by the reaction of naphthalenyl succinate with an androsterone-succinate-ethylenediamine conjugate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. In order to delineate the structural chemical requirements of naphthalene- androsterone some physicochemical descriptors were evaluated. The results showed an increase in the values of these for the naphthalene-androsterone derivative in comparison with naphthalenyl succinate and androsterone-succinate- ethylenediamine. These data suggest a relationship between the evaluated physicochemical parameters and the degree of lipophilicity of the naphthalene-androsterone derivative. Graphical abstract: [Figure not available: see fulltext.] © 2011 Springer-Verlag.
Idioma originalInglés estadounidense
Páginas (desde-hasta)1187-1191
Número de páginas1067
PublicaciónMonatshefte fur Chemie
DOI
EstadoPublicada - 1 nov 2011
Publicado de forma externa

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