A new naphthalene-androsterone derivative was synthesized by the reaction of naphthalenyl succinate with an androsterone-succinate-ethylenediamine conjugate in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. In order to delineate the structural chemical requirements of naphthalene- androsterone some physicochemical descriptors were evaluated. The results showed an increase in the values of these for the naphthalene-androsterone derivative in comparison with naphthalenyl succinate and androsterone-succinate- ethylenediamine. These data suggest a relationship between the evaluated physicochemical parameters and the degree of lipophilicity of the naphthalene-androsterone derivative. Graphical abstract: [Figure not available: see fulltext.] © 2011 Springer-Verlag.
Figueroa-Valverde, L., Díaz-Cedillo, F., López-Ramos, M., Garcia-Cervera, E., & Rivero-Rosado, V. (2011). Synthesis and theoretical QSAR study of a naphthalene-androsterone derivative. Monatshefte fur Chemie, 1187-1191. https://doi.org/10.1007/s00706-011-0584-5