TY - GEN
T1 - Some cardiovascular effects of inorganic arsenic exposure in children exposed to drinking water
AU - Osorio-Yáñez, C.
AU - Barrera-Hernández, A.
AU - Hernández-Castellanos, E.
AU - Sánchez-Peña, L. C.
AU - De Vizcaya-Ruiz, A.
AU - Del Razo, L. M.
AU - Ayllon-Vergara, J. C.
AU - Aguilar-Madrid, G.
AU - Arreola-Mendoza, L.
PY - 2014
Y1 - 2014
N2 - The present study investigates associations of inorganic arsenic (iAs) exposure, blood pressure and structural echocardiographic parameters in a cross sectional study of 173 Mexican children residents in an endemic area who presented concentrations of total speciated arsenic (tAs) in urine ranging from 5.7 to 370 ng As/mL. Results show that children in the highest exposure percentile (75th or <678 μg As/L/year) of cumulative As exposure (ΣAsE) were related to increased systolic or diastolic Blood Pressure (DBP), had higher Left Ventricular Mass (LVM) and increased Aortic Root Diameter (ARD) than children in the lowest exposure percentile p25th or <307 μg As/L/year). DBP and LVM were not related to iAs metabolites, but ARD were positively associated with the methyl-As (MAs) level in urine. In conclusion, we observed increased diastolic prehypertension and increased concentric left ventricular hypertrophy prevalence in children exposed to iAs.
AB - The present study investigates associations of inorganic arsenic (iAs) exposure, blood pressure and structural echocardiographic parameters in a cross sectional study of 173 Mexican children residents in an endemic area who presented concentrations of total speciated arsenic (tAs) in urine ranging from 5.7 to 370 ng As/mL. Results show that children in the highest exposure percentile (75th or <678 μg As/L/year) of cumulative As exposure (ΣAsE) were related to increased systolic or diastolic Blood Pressure (DBP), had higher Left Ventricular Mass (LVM) and increased Aortic Root Diameter (ARD) than children in the lowest exposure percentile p25th or <307 μg As/L/year). DBP and LVM were not related to iAs metabolites, but ARD were positively associated with the methyl-As (MAs) level in urine. In conclusion, we observed increased diastolic prehypertension and increased concentric left ventricular hypertrophy prevalence in children exposed to iAs.
UR - http://www.scopus.com/inward/record.url?scp=84907343005&partnerID=8YFLogxK
U2 - 10.1201/b16767-199
DO - 10.1201/b16767-199
M3 - Contribución a la conferencia
AN - SCOPUS:84907343005
SN - 9781138001411
T3 - One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
SP - 535
EP - 539
BT - One Century of the Discovery of Arsenicosis in Latin America (1914-2014)
PB - CRC Press/Balkema
T2 - 5th International Congress on Arsenic in the Environment, As 2014
Y2 - 11 May 2014 through 16 May 2014
ER -