Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)

Eloy Gasca-Pérez, Marcela Galar-Martínez, Sandra García-Medina, Isabel A. Pérez-Coyotl, Karina Ruiz-Lara, Selene Cano-Viveros, Ricardo Pérez-Pastén Borja, Leobardo M. Gómez-Oliván

Research output: Contribution to journalArticleResearchpeer-review

Abstract

© 2018 The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).
Original languageAmerican English
Pages (from-to)96-103
Number of pages85
JournalEnvironmental Toxicology and Pharmacology
DOIs
StatePublished - 1 Feb 2019

Fingerprint

Oxidative stress
Carps
Carbamazepine
Oxidative Stress
Hydrogen Peroxide
Lipid Peroxidation
Lipids
Liquid chromatography
Biomarkers
Glutathione Peroxidase
Liver
Catalase
Superoxide Dismutase
Brain
Diodes
Proteins
Antioxidants
Liquid Chromatography
Tissue
Detectors

Cite this

Gasca-Pérez, Eloy ; Galar-Martínez, Marcela ; García-Medina, Sandra ; Pérez-Coyotl, Isabel A. ; Ruiz-Lara, Karina ; Cano-Viveros, Selene ; Pérez-Pastén Borja, Ricardo ; Gómez-Oliván, Leobardo M. / Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio). In: Environmental Toxicology and Pharmacology. 2019 ; pp. 96-103.
@article{223912f493e44f748a6398e2d5b8ddd7,
title = "Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)",
abstract = "{\circledC} 2018 The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).",
author = "Eloy Gasca-P{\'e}rez and Marcela Galar-Mart{\'i}nez and Sandra Garc{\'i}a-Medina and P{\'e}rez-Coyotl, {Isabel A.} and Karina Ruiz-Lara and Selene Cano-Viveros and {P{\'e}rez-Past{\'e}n Borja}, Ricardo and G{\'o}mez-Oliv{\'a}n, {Leobardo M.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.etap.2018.12.017",
language = "American English",
pages = "96--103",
journal = "Environmental Toxicology and Pharmacology",
issn = "1382-6689",
publisher = "Elsevier",

}

Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio). / Gasca-Pérez, Eloy; Galar-Martínez, Marcela; García-Medina, Sandra; Pérez-Coyotl, Isabel A.; Ruiz-Lara, Karina; Cano-Viveros, Selene; Pérez-Pastén Borja, Ricardo; Gómez-Oliván, Leobardo M.

In: Environmental Toxicology and Pharmacology, 01.02.2019, p. 96-103.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)

AU - Gasca-Pérez, Eloy

AU - Galar-Martínez, Marcela

AU - García-Medina, Sandra

AU - Pérez-Coyotl, Isabel A.

AU - Ruiz-Lara, Karina

AU - Cano-Viveros, Selene

AU - Pérez-Pastén Borja, Ricardo

AU - Gómez-Oliván, Leobardo M.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - © 2018 The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).

AB - © 2018 The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059673777&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85059673777&origin=inward

U2 - 10.1016/j.etap.2018.12.017

DO - 10.1016/j.etap.2018.12.017

M3 - Article

SP - 96

EP - 103

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

SN - 1382-6689

ER -