Short-term exposure to carbamazepine causes oxidative stress on common carp (Cyprinus carpio)

Eloy Gasca-Pérez, Marcela Galar-Martínez, Sandra García-Medina, Isabel A. Pérez-Coyotl, Karina Ruiz-Lara, Selene Cano-Viveros, Ricardo Pérez-Pastén Borja, Leobardo M. Gómez-Oliván

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© 2018 The aim of this research was to determine the bioconcentration factor and if subacute exposure to carbamazepine (2 mg L −1 ) modifies the oxidative state of liver, gills and brain of Cyprinus carpio. This was measured through the following biomarkers: hydroperoxide and protein carbonyl content, lipid peroxidation degree, as well as superoxide dismutase, catalase and glutathione peroxidase activity. Carbamazepine concentration in carp's tissue was also determined by liquid chromatography with a diode arrangement detector. An increase in lipid peroxidation degree, hydroperoxide and protein carbonyl content, and a decrease in the activity of the antioxidant enzymes (P < 0.05) with respect to control was observed. Also, there is an increase in the concentration of carbamazepina present in the organs with respect to the water in the system, which denotes bioconcentration of the drug. In conclusion, carbamazepine is bioconcentrated and produces oxidative stress on the common carp (C. carpio).
Original languageAmerican English
Pages (from-to)96-103
Number of pages85
JournalEnvironmental Toxicology and Pharmacology
StatePublished - 1 Feb 2019

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